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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effect of Resistance Training on Extracellular Matrix Adaptations in Skeletal Muscle of Older Rats
|
|---|---|
| Published in |
Frontiers in Physiology, April 2018
|
| DOI | 10.3389/fphys.2018.00374 |
| Pubmed ID | |
| Authors |
Vinicius Guzzoni, Manoel B. T. Ribeiro, Gisele N. Lopes, Rita de Cássia Marqueti, Rosângela V. de Andrade, Heloisa S. Selistre-de-Araujo, João L. Q. Durigan |
| Abstract |
Accumulation of connective tissue, particularly extracellular matrix (ECM) proteins, has been observed in skeletal muscles with advancing age. Resistance training (RT) has been widely recommended to attenuate age-induced sarcopenia, even though its effects on the components that control ECM turnover in skeletal muscles remain to be elucidated. Thus, the aim of this study was to determine the effects of RT on connective tissue content and gene expression of key components of ECM in the skeletal muscles of aged rats. Young (3 mo.) and older (21 mo.) adult male Wistar rats were submitted to a RT protocol (ladder climbing with 65, 85, 95, and 100% load), 3 times a week for 12 weeks. Forty-eight hours post-training, the soleus (SOL) and gastrocnemius (GAS) muscles were dissected for histological and mRNA analysis. RT mitigated the age-associated increase of connective tissue content in both muscles, even though mRNA levels of COL-1 and-3 were elevated in older trained rats. Overall, RT significantly elevated the gene expression of key components of connective tissue deposition (TGFβ and CTGF; MMP-2 and-9; TIMP-1 and-2) in the GAS and SOL muscles of older rats. In conclusion, RT blunted the age-induced accumulation of connective tissue concomitant to the upregulation of genes related to synthesis and degradation of the ECM network in the SOL and GAS muscles of older rats. Although our findings indicate that RT plays a crucial role reducing connective tissue accumulation in aged hindlimb muscles, key components of ECM turnover were paradoxically elevated. The phenotypic responses induced by RT were not accompanied by the gene expression of those components related to ECM turnover. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 20% |
| United Kingdom | 3 | 15% |
| Spain | 1 | 5% |
| Austria | 1 | 5% |
| France | 1 | 5% |
| Brazil | 1 | 5% |
| Norway | 1 | 5% |
| Australia | 1 | 5% |
| Colombia | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 5 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 10 | 50% |
| Members of the public | 10 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 90 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 14% |
| Student > Ph. D. Student | 12 | 13% |
| Student > Bachelor | 10 | 11% |
| Researcher | 7 | 8% |
| Student > Doctoral Student | 5 | 6% |
| Other | 12 | 13% |
| Unknown | 31 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 13 | 14% |
| Biochemistry, Genetics and Molecular Biology | 10 | 11% |
| Medicine and Dentistry | 10 | 11% |
| Nursing and Health Professions | 6 | 7% |
| Social Sciences | 5 | 6% |
| Other | 8 | 9% |
| Unknown | 38 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2018.
All research outputs
#2,866,595
of 23,577,761 outputs
Outputs from Frontiers in Physiology
#1,504
of 14,285 outputs
Outputs of similar age
#60,258
of 330,507 outputs
Outputs of similar age from Frontiers in Physiology
#71
of 467 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,285 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,507 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 467 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.