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Effects of Ginseng Supplementation and Endurance-Exercise in the Artery-Specific Vascular Responsiveness of Diabetic and Sedentary Rats

Overview of attention for article published in Frontiers in Physiology, May 2018
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Title
Effects of Ginseng Supplementation and Endurance-Exercise in the Artery-Specific Vascular Responsiveness of Diabetic and Sedentary Rats
Published in
Frontiers in Physiology, May 2018
DOI 10.3389/fphys.2018.00460
Pubmed ID
Authors

Juan M. Murias, Mao Jiang, Tomasz Dzialoszynski, Earl G. Noble

Abstract

This study examined the effects of 12 weeks North-American ginseng supplementation, exercise training, and sedentary behavior on vascular responses in type I diabetic rats. The following hypotheses were tested: (1) ginseng supplementation would result in improved vascular responsiveness and sensitivity; (2) exercise training would result in further improvement in these vascular responses; (3) control rats with no access to exercise would show a depressed vascular response compared to control rats that were not exposed to a sedentary lifestyle. Groups: non-diabetic sedentary control (CS), sedentary diabetic (DS), sedentary diabetic with ginseng supplementation (DS+GS), diabetic with ginseng supplementation and high-intensity endurance exercise (D+GS+EX), and control not exposed to sedentary behavior (C). Diabetes was induced by streptozotocin. Arteries were excised, cleaned, and mounted onto a myography system. Percent vasorelaxation to acetylcholine (ACh) (10-8 M ACh to 10-4 M ACh) of the carotid artery was similar in CS (57 ± 31%), C (66 ± 35%), DS (58 ± 36%), D+GS+Ex (71 ± 37%), and DS+GS (64 ± 37%) (p > 0.05). Percent vasorelaxation of the aorta was smaller in CS (23 ± 17%) compared to C (46 ± 35%), DS (60 ± 40%), D+GS+Ex (64 ± 40%), and DS+GS (56 ± 39%) (p < 0.05), and smaller in C compared to D+GS+Ex (p < 0.05). In the femoral, the percent vasorelaxation was reduced in DS (18 ± 16%) compared to all the other conditions (CS, 43 ± 22%; C, 79 ± 28%; D+GS+Ex, 55 ± 27%; DS+GS, 45 ± 26%; p < 0.05), but larger in C compared to the other conditions (CS, DS, D+GS+Ex, DS+GS; p < 0.05). Diabetes and sedentary lifestyle have detrimental effects on vascular responses that are evident in the femoral arteries of the diabetic rats. Ginseng supplementation restored the loss of sensitivity, with no added vascular protection of exercise training.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 25%
Student > Master 3 13%
Student > Bachelor 2 8%
Lecturer > Senior Lecturer 1 4%
Other 1 4%
Other 2 8%
Unknown 9 38%
Readers by discipline Count As %
Nursing and Health Professions 3 13%
Sports and Recreations 3 13%
Medicine and Dentistry 2 8%
Psychology 2 8%
Immunology and Microbiology 1 4%
Other 1 4%
Unknown 12 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2018.
All research outputs
#17,960,210
of 23,063,209 outputs
Outputs from Frontiers in Physiology
#7,258
of 13,801 outputs
Outputs of similar age
#237,032
of 326,692 outputs
Outputs of similar age from Frontiers in Physiology
#255
of 486 outputs
Altmetric has tracked 23,063,209 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,801 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,692 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 486 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.