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Plethysmographic Loops: A Window on the Lung Pathophysiology of COPD Patients

Overview of attention for article published in Frontiers in Physiology, May 2018
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Title
Plethysmographic Loops: A Window on the Lung Pathophysiology of COPD Patients
Published in
Frontiers in Physiology, May 2018
DOI 10.3389/fphys.2018.00484
Pubmed ID
Authors

Dejan Radovanovic, Matteo Pecchiari, Fabio Pirracchio, Camilla Zilianti, Edgardo D’Angelo, Pierachille Santus

Abstract

Plethysmographic alveolar pressure-flow (Palv-F) loops contain potentially relevant information about the pathophysiology of chronic obstructive pulmonary disease (COPD), but no quantitative analysis of these loops during spontaneous breathing has ever been performed. The area of the loop's inspiratory (Ains) and expiratory portion (Aexp), and the difference between the end-expiratory and end-inspiratory alveolar pressure (ΔPalv) were measured in 20 young, 20 elderly healthy subjects, and 130 stable COPD patients. Ains and ΔPalv increased by 55 and 78% from young to elderly subjects, and by 107 and 122% from elderly subjects to COPD patients, reflecting changes in mechanical heterogeneity, lung-units recruitment/derecruitment, and possibly air trapping occurring with aging and/or obstructive disease. Aexp increased by 38% from young to elderly subjects, and by 198% from elderly subjects to COPD patients, consistent with the additional contribution of tidal expiratory flow-limitation, which occurs only in COPD patients and affects Aexp only. In COPD patients, Aexp and ΔPalv showed a significant negative correlation with VC, FEV1, IC, and a significant positive correlation with RV/TLC. The results suggest that the analysis of plethysmographic Palv-F loops provides an insight of the pathophysiological factors, especially tidal expiratory flow-limitation, that affect lung function in COPD patients.

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Mendeley readers

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The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 29%
Researcher 4 17%
Student > Ph. D. Student 3 13%
Other 3 13%
Student > Bachelor 1 4%
Other 1 4%
Unknown 5 21%
Readers by discipline Count As %
Nursing and Health Professions 7 29%
Medicine and Dentistry 5 21%
Social Sciences 2 8%
Computer Science 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 1 4%
Unknown 7 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2018.
All research outputs
#20,490,710
of 23,053,613 outputs
Outputs from Frontiers in Physiology
#9,499
of 13,790 outputs
Outputs of similar age
#287,136
of 326,176 outputs
Outputs of similar age from Frontiers in Physiology
#359
of 489 outputs
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