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What Makes the Harderian Gland Transcriptome Different From Other Chicken Immune Tissues? A Gene Expression Comparative Analysis

Overview of attention for article published in Frontiers in Physiology, May 2018
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Title
What Makes the Harderian Gland Transcriptome Different From Other Chicken Immune Tissues? A Gene Expression Comparative Analysis
Published in
Frontiers in Physiology, May 2018
DOI 10.3389/fphys.2018.00492
Pubmed ID
Authors

Melissa S. Deist, Susan J. Lamont

Abstract

The Harderian gland is a sparsely characterized immune tissue known to play an important role in local immunity. The function of the Harderian gland, however, is not clearly defined. Measuring the expression of all genes using RNA-seq enables the identification of genes, pathways, or networks of interest. Our relative RNA-seq expression analysis compared the chicken Harderian gland transcriptome to other important primary and secondary immune tissues including the bursa of Fabricius, thymus, and spleen of non-challenged birds. A total of 2,386 transcripts were identified as highly expressed in the Harderian gland. Gene set enrichment showed the importance of G-protein coupled receptor signaling and several immune pathways. Among the genes highly expressed in the Harderian gland were 48 miRNAs, a category of genetic elements involved in regulation of gene expression. Several identified miRNAs have immune related functions. This analysis gives insight to the unique immune processes inherent in the Harderian gland.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 1 20%
Student > Ph. D. Student 1 20%
Student > Master 1 20%
Unknown 2 40%
Readers by discipline Count As %
Unspecified 1 20%
Nursing and Health Professions 1 20%
Immunology and Microbiology 1 20%
Unknown 2 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2018.
All research outputs
#18,623,070
of 23,070,218 outputs
Outputs from Frontiers in Physiology
#8,253
of 13,813 outputs
Outputs of similar age
#253,945
of 327,730 outputs
Outputs of similar age from Frontiers in Physiology
#296
of 475 outputs
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