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Mendeley readers
Attention Score in Context
| Title |
Blood-Derived microRNAs for Pancreatic Cancer Diagnosis: A Narrative Review and Meta-Analysis
|
|---|---|
| Published in |
Frontiers in Physiology, June 2018
|
| DOI | 10.3389/fphys.2018.00685 |
| Pubmed ID | |
| Authors |
Xiaodong Li, Pujun Gao, Yang Wang, Xiaocong Wang |
| Abstract |
microRNAs (miRNAs) have been reported to be aberrantly expressed in patients with pancreatic cancer. In present review we explored the biological roles of miRNAs in pancreatic cancer and their clinical value in diagnosis. In the systematic review, the potential value of miRNAs as biomarkers was investigated by reviewing the altered miRNA profiles reported in pancreatic cancer patients in 356 included studies. In the subsequent meta-analysis, we included 17 studies in early diagnosis of pancreatic cancer with a panel of altered miRNAs. The following results were obtained: pooled sensitivity of 0.88 (95% confidence interval [CI] 0.83-0.92), pooled specificity of 0.83 (95%CI 0.77-0.88), diagnostic odds ratio of 27 (95%CI 14-53), and area under the receiver operating characteristic curve of 0.90 (95%CI 0.88-0.93). To further explore the value of a single miRNA, the diagnostic value of miR-21 in PA was also demonstrated by the pooled sensitivity (0.90, 95% CI: 0.82-0.94), specificity (0.72, 95% CI: 0.57-0.83) as well as AUC (0.91 (95%CI 0.88-0.93). In conclusion, our findings suggest that aberrant miRNA expression in blood play an essential role in pancreatic cancer, and meta-analysis revealed blood-derived miRNAs as probable biomarkers for early diagnosis of pancreatic cancer. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 23% |
| Researcher | 5 | 17% |
| Student > Bachelor | 4 | 13% |
| Student > Ph. D. Student | 4 | 13% |
| Lecturer | 3 | 10% |
| Other | 3 | 10% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 27% |
| Biochemistry, Genetics and Molecular Biology | 7 | 23% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 10% |
| Agricultural and Biological Sciences | 2 | 7% |
| Chemical Engineering | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 5 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2018.
All research outputs
#18,641,800
of 23,094,276 outputs
Outputs from Frontiers in Physiology
#8,267
of 13,842 outputs
Outputs of similar age
#254,914
of 329,791 outputs
Outputs of similar age from Frontiers in Physiology
#336
of 497 outputs
Altmetric has tracked 23,094,276 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,842 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,791 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 497 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.