Title |
Nanotherapeutics for Treatment of Pulmonary Arterial Hypertension
|
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Published in |
Frontiers in Physiology, July 2018
|
DOI | 10.3389/fphys.2018.00890 |
Pubmed ID | |
Authors |
Victor Segura-Ibarra, Suhong Wu, Nida Hassan, Jose A. Moran-Guerrero, Mauro Ferrari, Ashrith Guha, Harry Karmouty-Quintana, Elvin Blanco |
Abstract |
Pulmonary arterial hypertension (PAH) is a devastating and fatal chronic lung disease. While current pharmacotherapies have improved patient quality of life, PAH drugs suffer from limitations in the form of short-term pharmacokinetics, instability, and poor organ specificity. Traditionally, nanotechnology-based delivery strategies have proven advantageous at increasing both circulation lifetimes of chemotherapeutics and accumulation in tumors due to enhanced permeability through fenestrated vasculature. Importantly, increased nanoparticle (NP) accumulation in diseased tissues has been observed pre-clinically in pathologies characterized by endothelial dysfunction and remodeled vasculature, including myocardial infarction and heart failure. Recently, this phenomenon has also been observed in preclinical models of PAH, leading to the exploration of NP-based drug delivery as a therapeutic modality in PAH. Herein, we discussed the advantages of NPs for efficacious treatment of PAH, including heightened therapeutic delivery to diseased lungs for increased drug bioavailability, as well as highlighted innovative nanotherapeutic approaches for PAH. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 25% |
Student > Master | 7 | 14% |
Researcher | 4 | 8% |
Professor > Associate Professor | 4 | 8% |
Student > Bachelor | 3 | 6% |
Other | 6 | 12% |
Unknown | 14 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 25% |
Medicine and Dentistry | 9 | 18% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Agricultural and Biological Sciences | 3 | 6% |
Chemistry | 2 | 4% |
Other | 3 | 6% |
Unknown | 18 | 35% |