Title |
Autophagy Dysfunction and Oxidative Stress, Two Related Mechanisms Implicated in Retinitis Pigmentosa
|
---|---|
Published in |
Frontiers in Physiology, July 2018
|
DOI | 10.3389/fphys.2018.01008 |
Pubmed ID | |
Authors |
Mari-Luz Moreno, Salvador Mérida, Francisco Bosch-Morell, María Miranda, Vincent M. Villar |
Abstract |
Retinitis pigmentosa (RP) is one of the most common clinical subtypes of retinal degeneration (RD), and it is a neurodegenerative disease that could cause complete blindness in humans because it ultimately affects the photoreceptors viability. RP afflicts an estimated 1.5 million patients worldwide. The retina is highly susceptible to oxidative stress which can impair mitochondrial function. Many retina pathologies, such as diabetic retinopathy and secondary cone photoreceptor death in RP, have been related directly or indirectly with mitochondrial dysfunction. The possible role of autophagy in retina and cell differentiation is described and also the implications of autophagy dysregulation in RP. The present review shows the crucial role of autophagy in maintaining the retina homeostasis and possible therapeutic approaches for the treatment of RP. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 25% |
Switzerland | 1 | 13% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 88% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 12% |
Student > Ph. D. Student | 6 | 11% |
Student > Master | 6 | 11% |
Student > Bachelor | 5 | 9% |
Student > Doctoral Student | 4 | 7% |
Other | 8 | 14% |
Unknown | 21 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 21% |
Medicine and Dentistry | 8 | 14% |
Neuroscience | 6 | 11% |
Nursing and Health Professions | 2 | 4% |
Unspecified | 2 | 4% |
Other | 5 | 9% |
Unknown | 22 | 39% |