Title |
bZIPs and WRKYs: two large transcription factor families executing two different functional strategies
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Published in |
Frontiers in Plant Science, April 2014
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DOI | 10.3389/fpls.2014.00169 |
Pubmed ID | |
Authors |
Carles M. Llorca, Maren Potschin, Ulrike Zentgraf |
Abstract |
bZIPs and WRKYs are two important plant transcription factor (TF) families regulating diverse developmental and stress-related processes. Since a partial overlap in these biological processes is obvious, it can be speculated that they fulfill non-redundant functions in a complex regulatory network. Here, we focus on the regulatory mechanisms that are so far described for bZIPs and WRKYs. bZIP factors need to heterodimerize for DNA-binding and regulation of transcription, and based on a bioinformatics approach, bZIPs can build up more than the double of protein interactions than WRKYs. In contrast, an enrichment of the WRKY DNA-binding motifs can be found in WRKY promoters, a phenomenon which is not observed for the bZIP family. Thus, the two TF families follow two different functional strategies in which WRKYs regulate each other's transcription in a transcriptional network whereas bZIP action relies on intensive heterodimerization. |
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Switzerland | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Germany | 1 | <1% |
Chile | 1 | <1% |
France | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 208 | 98% |
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Researcher | 27 | 13% |
Student > Master | 19 | 9% |
Student > Doctoral Student | 19 | 9% |
Student > Bachelor | 19 | 9% |
Other | 32 | 15% |
Unknown | 32 | 15% |
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Engineering | 2 | <1% |
Neuroscience | 2 | <1% |
Other | 4 | 2% |
Unknown | 35 | 16% |