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Salicylic acid signal transduction: the initiation of biosynthesis, perception and transcriptional reprogramming

Overview of attention for article published in Frontiers in Plant Science, December 2014
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  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

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Title
Salicylic acid signal transduction: the initiation of biosynthesis, perception and transcriptional reprogramming
Published in
Frontiers in Plant Science, December 2014
DOI 10.3389/fpls.2014.00697
Pubmed ID
Authors

Carolin Seyfferth, Kenichi Tsuda

Abstract

The phytohormone salicylic acid (SA) is a small phenolic compound that regulates diverse physiological processes, in particular plant resistance against pathogens. Understanding SA-mediated signaling has been a major focus of plant research. Pathogen-induced SA is mainly synthesized via the isochorismate pathway in chloroplasts, with ICS1 (ISOCHORISMATE SYNTHASE 1) being a critical enzyme. Calcium signaling regulates activities of a subset of transcription factors thereby activating nuclear ICS1 expression. The produced SA triggers extensive transcriptional reprogramming in which NPR1 (NON-EXPRESSOR of PATHOGENESIS-RELATED GENES 1) functions as the central coactivator of TGA transcription factors. Recently, two alternative but not exclusive models for SA perception mechanisms were proposed. The first model is that NPR1 homologs, NPR3 and NPR4, perceive SA thereby regulating NPR1 protein accumulation. The second model describes that NPR1 itself perceives SA, triggering an NPR1 conformational change thereby activating SA-mediated transcription. Besides the direct SA binding, NPR1 is also regulated by SA-mediated redox changes and phosphorylation. Emerging evidence show that pathogen virulence effectors target SA signaling, further strengthening the importance of SA-mediated immunity.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 396 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
Japan 1 <1%
Mexico 1 <1%
Ireland 1 <1%
Unknown 391 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 104 26%
Student > Master 52 13%
Researcher 50 13%
Student > Bachelor 43 11%
Student > Doctoral Student 25 6%
Other 51 13%
Unknown 71 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 204 52%
Biochemistry, Genetics and Molecular Biology 81 20%
Environmental Science 4 1%
Chemistry 3 <1%
Immunology and Microbiology 3 <1%
Other 18 5%
Unknown 83 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2014.
All research outputs
#14,204,846
of 22,771,140 outputs
Outputs from Frontiers in Plant Science
#8,126
of 20,070 outputs
Outputs of similar age
#191,583
of 361,031 outputs
Outputs of similar age from Frontiers in Plant Science
#81
of 201 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 20,070 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,031 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 201 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.