Title |
Phloroglucinol and Terpenoid Derivatives from Hypericum cistifolium and H. galioides (Hypericaceae)
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Published in |
Frontiers in Plant Science, July 2016
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DOI | 10.3389/fpls.2016.00961 |
Pubmed ID | |
Authors |
Sara L. Crockett, Olaf Kunert, Eva-Maria Pferschy-Wenzig, Melissa Jacob, Wolfgang Schuehly, Rudolf Bauer |
Abstract |
A new simple phloroglucinol derivative characterized as 1-(6-hydroxy-2,4-dimethoxyphenyl)-2-methyl-1-propanone (1) was isolated from Hypericum cistifolium (Hypericaceae) as a major constituent of the non-polar plant extract. Minor amounts of this new compound, in addition to two known structurally related phloroglucinol derivatives (2 and 3), and two new terpenoid derivatives characterized, respectively, as 2-benzoyl-3,3-dimethyl-4R,6S-bis-(3-methylbut-2-enyl)-cyclohexanone (4a) and 2-benzoyl-3,3-dimethyl-4S,6R-bis-(3-methylbut-2-enyl)-cyclohexanone (4b), were isolated from a related species, H. galioides Lam. The chemical structures were established using 2D-NMR spectroscopy and mass spectrometry. These compounds were evaluated in vitro for antimicrobial activity against a panel of pathogenic microorganisms and anti-inflammatory activity through inhibition of COX-1, COX-2, and 5-LOX catalyzed LTB4 formation. |
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Germany | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
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Unknown | 22 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 5 | 23% |
Student > Master | 3 | 14% |
Student > Doctoral Student | 3 | 14% |
Lecturer > Senior Lecturer | 1 | 5% |
Other | 1 | 5% |
Other | 3 | 14% |
Unknown | 6 | 27% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 7 | 32% |
Agricultural and Biological Sciences | 4 | 18% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Unspecified | 1 | 5% |
Chemistry | 1 | 5% |
Other | 0 | 0% |
Unknown | 7 | 32% |