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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Comparative Analysis of Ralstonia solanacearum Methylomes
|
|---|---|
| Published in |
Frontiers in Plant Science, April 2017
|
| DOI | 10.3389/fpls.2017.00504 |
| Pubmed ID | |
| Authors |
Ivan Erill, Marina Puigvert, Ludovic Legrand, Rodrigo Guarischi-Sousa, Céline Vandecasteele, João C. Setubal, Stephane Genin, Alice Guidot, Marc Valls |
| Abstract |
Ralstonia solanacearum is an important soil-borne plant pathogen with broad geographical distribution and the ability to cause wilt disease in many agriculturally important crops. Genome sequencing of multiple R. solanacearum strains has identified both unique and shared genetic traits influencing their evolution and ability to colonize plant hosts. Previous research has shown that DNA methylation can drive speciation and modulate virulence in bacteria, but the impact of epigenetic modifications on the diversification and pathogenesis of R. solanacearum is unknown. Sequencing of R. solanacearum strains GMI1000 and UY031 using Single Molecule Real-Time technology allowed us to perform a comparative analysis of R. solanacearum methylomes. Our analysis identified a novel methylation motif associated with a DNA methylase that is conserved in all complete Ralstonia spp. genomes and across the Burkholderiaceae, as well as a methylation motif associated to a phage-borne methylase unique to R. solanacearum UY031. Comparative analysis of the conserved methylation motif revealed that it is most prevalent in gene promoter regions, where it displays a high degree of conservation detectable through phylogenetic footprinting. Analysis of hyper- and hypo-methylated loci identified several genes involved in global and virulence regulatory functions whose expression may be modulated by DNA methylation. Analysis of genome-wide modification patterns identified a significant correlation between DNA modification and transposase genes in R. solanacearum UY031, driven by the presence of a high copy number of ISrso3 insertion sequences in this genome and pointing to a novel mechanism for regulation of transposition. These results set a firm foundation for experimental investigations into the role of DNA methylation in R. solanacearum evolution and its adaptation to different plants. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 15% |
| France | 2 | 15% |
| Saint Barthélemy | 1 | 8% |
| Netherlands | 1 | 8% |
| Switzerland | 1 | 8% |
| Unknown | 6 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 69% |
| Scientists | 4 | 31% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 52 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 38% |
| Student > Master | 10 | 19% |
| Researcher | 5 | 9% |
| Student > Bachelor | 2 | 4% |
| Student > Doctoral Student | 2 | 4% |
| Other | 6 | 11% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 47% |
| Biochemistry, Genetics and Molecular Biology | 12 | 23% |
| Immunology and Microbiology | 3 | 6% |
| Environmental Science | 1 | 2% |
| Social Sciences | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 9 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2021.
All research outputs
#5,113,367
of 24,707,218 outputs
Outputs from Frontiers in Plant Science
#2,754
of 23,544 outputs
Outputs of similar age
#84,449
of 314,711 outputs
Outputs of similar age from Frontiers in Plant Science
#75
of 561 outputs
Altmetric has tracked 24,707,218 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 23,544 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,711 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 561 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.