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Identification of a Novel (-)-5-Epieremophilene Synthase from Salvia miltiorrhiza via Transcriptome Mining

Overview of attention for article published in Frontiers in Plant Science, April 2017
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Title
Identification of a Novel (-)-5-Epieremophilene Synthase from Salvia miltiorrhiza via Transcriptome Mining
Published in
Frontiers in Plant Science, April 2017
DOI 10.3389/fpls.2017.00627
Pubmed ID
Authors

Xin Fang, Chen-Yi Li, Yue Yang, Meng-Ying Cui, Xiao-Ya Chen, Lei Yang

Abstract

Salvia miltiorrhiza, a medicinal plant in China, has been used for thousands of years to treat coronary heart diseases. Although biosynthesis of tanshinones, a group of diterpenoids in S. miltiorrhiza, has been extensively investigated, to date we know little about the formation of monoterpenes and sesquiterpenes in this medicinal plant. Here, we report the characterization of three sesquiterpene synthases, named SmSTPS1, SmSTPS2, and SmSTPS3, which catalyzed the formation of a new compound, (-)-5-epieremophilene. Additionally, the (-)-5-epieremophilene biosynthesis activity of SmSTPS1 was confirmed by transient expression in Nicotiana benthamiana. Despite the similar enzyme activities of SmSTPS1, SmSTPS2, and SmSTPS3, the three (-)-5-epieremophilene synthase genes displayed different spatial expression patterns and responded differently to hormone treatments, implicating their specific roles in plant-environment interactions. Our results provide valuable data to understanding the biosynthesis and composition of terpenes in plant.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 23%
Student > Ph. D. Student 5 23%
Student > Bachelor 3 14%
Student > Postgraduate 2 9%
Student > Master 2 9%
Other 2 9%
Unknown 3 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 50%
Biochemistry, Genetics and Molecular Biology 4 18%
Chemical Engineering 1 5%
Chemistry 1 5%
Unknown 5 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2017.
All research outputs
#20,420,242
of 22,971,207 outputs
Outputs from Frontiers in Plant Science
#16,304
of 20,408 outputs
Outputs of similar age
#269,400
of 309,761 outputs
Outputs of similar age from Frontiers in Plant Science
#495
of 584 outputs
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So far Altmetric has tracked 20,408 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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