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Endocytosis of AtRGS1 Is Regulated by the Autophagy Pathway after D-Glucose Stimulation

Overview of attention for article published in Frontiers in Plant Science, July 2017
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Title
Endocytosis of AtRGS1 Is Regulated by the Autophagy Pathway after D-Glucose Stimulation
Published in
Frontiers in Plant Science, July 2017
DOI 10.3389/fpls.2017.01229
Pubmed ID
Authors

Quanquan Yan, Jingchun Wang, Zheng Qing Fu, Wenli Chen

Abstract

Sugar, as a signal molecule, has significant functions in signal transduction in which the seven-transmembrane regulator of G-protein signaling (RGS1) protein participates. D-Glucose causes endocytosis of the AtRGS1, leading to the physical uncoupling of AtRGS1 from AtGPA1 and thus a release of the GAP activity and concomitant sustained activation of G-protein signaling. Autophagy involves in massive degradation and recycling of cytoplasmic components to survive environmental stresses. The function of autophagy in AtRGS1 endocytosis during D-glucose stimulation has not been elucidated. In this study, we investigate the relationship between autophagy and AtRGS1 in response to D-glucose. Our findings demonstrated that AtRGS1 mediated the activation of autophagy by affecting the activities of the five functional groups of protein complexes and promoted the formation of autophagosomes under D-glucose application. When the autophagy pathway was interrupted, AtRGS1 recovery increased and endocytosis of ATRGS1 was inhibited, indicating that autophagy pathway plays an important role in regulating the endocytosis and recovery of AtRGS1 after D-glucose stimulation.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 32%
Student > Doctoral Student 5 18%
Student > Bachelor 3 11%
Student > Master 3 11%
Researcher 2 7%
Other 1 4%
Unknown 5 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 39%
Biochemistry, Genetics and Molecular Biology 8 29%
Social Sciences 1 4%
Chemistry 1 4%
Unknown 7 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2017.
All research outputs
#18,560,904
of 22,988,380 outputs
Outputs from Frontiers in Plant Science
#13,940
of 20,454 outputs
Outputs of similar age
#239,297
of 312,615 outputs
Outputs of similar age from Frontiers in Plant Science
#425
of 534 outputs
Altmetric has tracked 22,988,380 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 20,454 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,615 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 534 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.