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Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants

Overview of attention for article published in Frontiers in Psychology, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

blogs
3 blogs
twitter
10 X users
facebook
8 Facebook pages

Readers on

mendeley
37 Mendeley
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Title
Taking the Perspective that a Depressive State Reflects Inflammation: Implications for the Use of Antidepressants
Published in
Frontiers in Psychology, January 2012
DOI 10.3389/fpsyg.2012.00297
Pubmed ID
Authors

Jill Leslie Littrell

Abstract

This paper reviews both the evidence that supports the characterization of depression as an inflammatory disorder and the different biochemical mechanisms that have been postulated for the connection between inflammation and depression. This association offers credible explanation for the short term efficacy of antidepressants, which have short term anti-inflammatory effects. Evidence for those anti-inflammatory effects is discussed. Evidence of the contrary long-term effects of antidepressants, which increase rather than decrease inflammation, is also reviewed. It is argued that this increase in inflammation would predict an increase in chronicity among depressed patients that have been treated with antidepressants drugs, which has been noted in the literature. A brief discussion of alternatives for decreasing inflammation, some of which have demonstrated efficacy in ameliorating depression, is presented.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Taiwan 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 22%
Student > Ph. D. Student 5 14%
Researcher 4 11%
Student > Master 4 11%
Other 3 8%
Other 5 14%
Unknown 8 22%
Readers by discipline Count As %
Medicine and Dentistry 6 16%
Agricultural and Biological Sciences 4 11%
Nursing and Health Professions 3 8%
Psychology 3 8%
Social Sciences 2 5%
Other 6 16%
Unknown 13 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2019.
All research outputs
#1,294,408
of 24,836,260 outputs
Outputs from Frontiers in Psychology
#2,661
of 33,498 outputs
Outputs of similar age
#8,433
of 254,890 outputs
Outputs of similar age from Frontiers in Psychology
#46
of 481 outputs
Altmetric has tracked 24,836,260 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,498 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 254,890 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 481 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.