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Self-reported sleep duration mitigates the association between inflammation and cognitive functioning in hospitalized older men

Overview of attention for article published in Frontiers in Psychology, July 2015
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Title
Self-reported sleep duration mitigates the association between inflammation and cognitive functioning in hospitalized older men
Published in
Frontiers in Psychology, July 2015
DOI 10.3389/fpsyg.2015.01004
Pubmed ID
Authors

Joseph M. Dzierzewski, Yeonsu Song, Constance H. Fung, Juan C. Rodriguez, Stella Jouldjian, Cathy A. Alessi, Elizabeth C. Breen, Michael R. Irwin, Jennifer L. Martin

Abstract

Examination of predictors of late-life cognitive functioning is particularly salient in at-risk older adults, such as those who have been recently hospitalized. Sleep and inflammation are independently related to late-life cognitive functioning. The potential role of sleep as a moderator of the relationship between inflammation and global cognitive functioning has not been adequately addressed. We examined the relationship between self-reported sleep duration, inflammatory markers, and general cognitive functioning in hospitalized older men. Older men (n = 135; Mean age = 72.9 ± 9.7 years) were recruited from inpatient rehabilitation units at a VA Medical Center to participate in a cross-sectional study of sleep. Participants completed the Mini-Mental State Examination and Pittsburgh Sleep Quality Index, and underwent an 8 a.m. blood draw to measure inflammatory markers [i.e., C-reactive protein (CRP), tumor necrosis factor alpha (TNFα), soluble intercellular adhesion molecule-1 (sICAM-1), and interleukin-6 (IL-6)]. Hierarchical regression analyses (controlling for age, education, race, depression, pain, health comorbidity, and BMI) revealed that higher levels of CRP and sICAM are associated with higher global cognitive functioning in older men with sleep duration ≥6 h (β = -0.19, β = -0.18, p's < 0.05, respectively), but not in those with short sleep durations (p's > 0.05). In elderly hospitalized men, sleep duration moderates the association between inflammation and cognitive functioning. These findings have implications for the clinical care of older men within medical settings.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 20%
Researcher 5 11%
Student > Ph. D. Student 5 11%
Student > Bachelor 4 9%
Student > Doctoral Student 3 7%
Other 7 16%
Unknown 11 25%
Readers by discipline Count As %
Medicine and Dentistry 11 25%
Psychology 7 16%
Nursing and Health Professions 4 9%
Neuroscience 3 7%
Agricultural and Biological Sciences 2 5%
Other 3 7%
Unknown 14 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2015.
All research outputs
#17,765,819
of 22,817,213 outputs
Outputs from Frontiers in Psychology
#20,439
of 29,760 outputs
Outputs of similar age
#177,279
of 264,073 outputs
Outputs of similar age from Frontiers in Psychology
#455
of 573 outputs
Altmetric has tracked 22,817,213 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
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