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Catechol-O-methyltransferase val158met Polymorphism Interacts with Sex to Affect Face Recognition Ability

Overview of attention for article published in Frontiers in Psychology, June 2016
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Title
Catechol-O-methyltransferase val158met Polymorphism Interacts with Sex to Affect Face Recognition Ability
Published in
Frontiers in Psychology, June 2016
DOI 10.3389/fpsyg.2016.00965
Pubmed ID
Authors

Yvette N. Lamb, Nicole S. McKay, Shrimal S. Singh, Karen E. Waldie, Ian J. Kirk

Abstract

The catechol-O-methyltransferase (COMT) val158met polymorphism affects the breakdown of synaptic dopamine. Consequently, this polymorphism has been associated with a variety of neurophysiological and behavioral outcomes. Some of the effects have been found to be sex-specific and it appears estrogen may act to down-regulate the activity of the COMT enzyme. The dopaminergic system has been implicated in face recognition, a form of cognition for which a female advantage has typically been reported. This study aimed to investigate potential joint effects of sex and COMT genotype on face recognition. A sample of 142 university students was genotyped and assessed using the Faces I subtest of the Wechsler Memory Scale - Third Edition (WMS-III). A significant two-way interaction between sex and COMT genotype on face recognition performance was found. Of the male participants, COMT val homozygotes and heterozygotes had significantly lower scores than met homozygotes. Scores did not differ between genotypes for female participants. While male val homozygotes had significantly lower scores than female val homozygotes, no sex differences were observed in the heterozygotes and met homozygotes. This study contributes to the accumulating literature documenting sex-specific effects of the COMT polymorphism by demonstrating a COMT-sex interaction for face recognition, and is consistent with a role for dopamine in face recognition.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 18%
Researcher 3 18%
Student > Doctoral Student 1 6%
Professor 1 6%
Student > Master 1 6%
Other 3 18%
Unknown 5 29%
Readers by discipline Count As %
Neuroscience 4 24%
Psychology 3 18%
Medicine and Dentistry 2 12%
Immunology and Microbiology 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 0 0%
Unknown 6 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2016.
All research outputs
#15,688,569
of 23,313,051 outputs
Outputs from Frontiers in Psychology
#19,282
of 31,000 outputs
Outputs of similar age
#225,028
of 353,740 outputs
Outputs of similar age from Frontiers in Psychology
#286
of 399 outputs
Altmetric has tracked 23,313,051 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,000 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
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We're also able to compare this research output to 399 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.