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Mendeley readers
Attention Score in Context
| Title |
Abnormal Left-Sided Orbitomedial Prefrontal Cortical–Amygdala Connectivity during Happy and Fear Face Processing: A Potential Neural Mechanism of Female MDD
|
|---|---|
| Published in |
Frontiers in Psychiatry, January 2011
|
| DOI | 10.3389/fpsyt.2011.00069 |
| Pubmed ID | |
| Authors |
Jorge Renner Cardoso de Almeida, Dina Michaela Kronhaus, Etienne L. Sibille, Scott A. Langenecker, Amelia Versace, Edmund James LaBarbara, Mary Louise Phillips |
| Abstract |
Background: Pathophysiologic processes supporting abnormal emotion regulation in major depressive disorder (MDD) are poorly understood. We previously found abnormal inverse left-sided ventromedial prefrontal cortical-amygdala effective connectivity to happy faces in females with MDD. We aimed to replicate and expand this previous finding in an independent participant sample, using a more inclusive neural model, and a novel emotion processing paradigm. Methods: Nineteen individuals with MDD in depressed episode (12 females), and 19 healthy individuals, age, and gender matched, performed an implicit emotion processing and automatic attentional control paradigm to examine abnormalities in prefrontal cortical-amygdala neural circuitry during happy, angry, fearful, and sad face processing measured with functional magnetic resonance imaging in a 3-T scanner. Effective connectivity was estimated with dynamic causal modeling in a trinodal neural model including two anatomically defined prefrontal cortical regions, ventromedial prefrontal cortex, and subgenual cingulate cortex (sgACC), and the amygdala. Results: We replicated our previous finding of abnormal inverse left-sided top-down ventromedial prefrontal cortical-amygdala connectivity to happy faces in females with MDD (p = 0.04), and also showed a similar pattern of abnormal inverse left-sided sgACC-amygdala connectivity to these stimuli (p = 0.03). These findings were paralleled by abnormally reduced positive left-sided ventromedial prefrontal cortical-sgACC connectivity to happy faces in females with MDD (p = 0.008), and abnormally increased positive left-sided sgACC-amygdala connectivity to fearful faces in females, and all individuals, with MDD (p = 0.008; p = 0.003). Conclusion: Different patterns of abnormal prefrontal cortical-amygdala connectivity to happy and fearful stimuli might represent neural mechanisms for the excessive self-reproach and comorbid anxiety that characterize female MDD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Netherlands | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 109 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 19% |
| Researcher | 13 | 12% |
| Professor > Associate Professor | 12 | 11% |
| Student > Master | 10 | 9% |
| Student > Bachelor | 8 | 7% |
| Other | 20 | 18% |
| Unknown | 28 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 32 | 29% |
| Neuroscience | 16 | 14% |
| Medicine and Dentistry | 13 | 12% |
| Agricultural and Biological Sciences | 10 | 9% |
| Engineering | 4 | 4% |
| Other | 6 | 5% |
| Unknown | 31 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2011.
All research outputs
#20,165,369
of 22,675,759 outputs
Outputs from Frontiers in Psychiatry
#7,598
of 9,789 outputs
Outputs of similar age
#169,848
of 180,328 outputs
Outputs of similar age from Frontiers in Psychiatry
#31
of 36 outputs
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