You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Immediate Effects of tDCS on the μ-Opioid System of a Chronic Pain Patient
|
|---|---|
| Published in |
Frontiers in Psychiatry, January 2012
|
| DOI | 10.3389/fpsyt.2012.00093 |
| Pubmed ID | |
| Authors |
Marcos Fabio DosSantos, Tiffany M. Love, Ilkka Kristian Martikainen, Thiago Dias Nascimento, Felipe Fregni, Chelsea Cummiford, Misty Dawn Deboer, Jon-Kar Zubieta, Alexandre F. M. DaSilva |
| Abstract |
We developed a unique protocol where transcranial direct current stimulation (tDCS) of the motor cortex is performed during positron emission tomography (PET) scan using a μ-opioid receptor (μOR) selective radiotracer, [(11)C]carfentanil. This is one of the most important central neuromechanisms associated with pain perception and regulation. We measured μOR non-displaceable binding potential (μOR BP(ND)) in a trigeminal neuropathic pain patient (TNP) without creating artifacts, or posing risks to the patient (e.g., monitoring of resistance). The active session directly improved in 36.2% the threshold for experimental cold pain in the trigeminal allodynic area, mandibular branch, but not the TNP patient's clinical pain. Interestingly, the single active tDCS application considerably decreased μORBP(ND) levels in (sub)cortical pain-matrix structures compared to sham tDCS, especially in the posterior thalamus. Suggesting that the μ-opioidergic effects of a single tDCS session are subclinical at immediate level, and repetitive sessions are necessary to revert ingrained neuroplastic changes related to the chronic pain. To our knowledge, we provide data for the first time in vivo that there is possibly an instant increase of endogenous μ-opioid release during acute motor cortex neuromodulation with tDCS. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 23% |
| United Kingdom | 2 | 8% |
| Canada | 2 | 8% |
| Costa Rica | 1 | 4% |
| Switzerland | 1 | 4% |
| Singapore | 1 | 4% |
| South Africa | 1 | 4% |
| Belgium | 1 | 4% |
| Spain | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 9 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 77% |
| Scientists | 4 | 15% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 175 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 18% |
| Student > Ph. D. Student | 30 | 17% |
| Student > Master | 24 | 13% |
| Student > Bachelor | 17 | 9% |
| Professor > Associate Professor | 13 | 7% |
| Other | 38 | 21% |
| Unknown | 25 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 20% |
| Neuroscience | 36 | 20% |
| Psychology | 24 | 13% |
| Agricultural and Biological Sciences | 15 | 8% |
| Engineering | 8 | 4% |
| Other | 24 | 13% |
| Unknown | 37 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2017.
All research outputs
#707,562
of 25,708,267 outputs
Outputs from Frontiers in Psychiatry
#418
of 12,875 outputs
Outputs of similar age
#3,808
of 251,638 outputs
Outputs of similar age from Frontiers in Psychiatry
#2
of 87 outputs
Altmetric has tracked 25,708,267 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,875 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,638 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.