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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sex-Specific and Strain-Dependent Effects of Early Life Adversity on Behavioral and Epigenetic Outcomes
|
|---|---|
| Published in |
Frontiers in Psychiatry, January 2013
|
| DOI | 10.3389/fpsyt.2013.00078 |
| Pubmed ID | |
| Authors |
Marija Kundakovic, Sean Lim, Kathryn Gudsnuk, Frances A. Champagne |
| Abstract |
Early life adversity can have a significant long-term impact with implications for the emergence of psychopathology. Disruption to mother-infant interactions is a form of early life adversity that may, in particular, have profound programing effects on the developing brain. However, despite converging evidence from human and animal studies, the precise mechanistic pathways underlying adversity-associated neurobehavioral changes have yet to be elucidated. One approach to the study of mechanism is exploration of epigenetic changes associated with early life experience. In the current study, we examined the effects of postnatal maternal separation (MS) in mice and assessed the behavioral, brain gene expression, and epigenetic effects of this manipulation in offspring. Importantly, we included two different mouse strains (C57BL/6J and Balb/cJ) and both male and female offspring to determine strain- and/or sex-associated differential response to MS. We found both strain-specific and sex-dependent effects of MS in early adolescent offspring on measures of open-field exploration, sucrose preference, and social behavior. Analyses of cortical and hippocampal mRNA levels of the glucocorticoid receptor (Nr3c1) and brain-derived neurotrophic factor (Bdnf) genes revealed decreased hippocampal Bdnf expression in maternally separated C57BL/6J females and increased cortical Bdnf expression in maternally separated male and female Balb/cJ offspring. Analyses of Nr3c1and Bdnf (IV and IX) CpG methylation indicated increased hippocampal Nr3c1 methylation in maternally separated C57BL/6J males and increased hippocampal Bdnf IX methylation in male and female maternally separated Balb/c mice. Overall, though effect sizes were modest, these findings suggest a complex interaction between early life adversity, genetic background, and sex in the determination of neurobehavioral and epigenetic outcomes that may account for differential vulnerability to later-life disorder. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 213 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | <1% |
| South Africa | 1 | <1% |
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| Denmark | 1 | <1% |
| Argentina | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 204 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 58 | 27% |
| Researcher | 29 | 14% |
| Student > Bachelor | 22 | 10% |
| Student > Master | 19 | 9% |
| Student > Doctoral Student | 15 | 7% |
| Other | 37 | 17% |
| Unknown | 33 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 44 | 21% |
| Agricultural and Biological Sciences | 39 | 18% |
| Psychology | 29 | 14% |
| Medicine and Dentistry | 27 | 13% |
| Biochemistry, Genetics and Molecular Biology | 16 | 8% |
| Other | 11 | 5% |
| Unknown | 47 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2014.
All research outputs
#2,688,907
of 22,715,151 outputs
Outputs from Frontiers in Psychiatry
#1,394
of 9,834 outputs
Outputs of similar age
#28,501
of 280,748 outputs
Outputs of similar age from Frontiers in Psychiatry
#51
of 185 outputs
Altmetric has tracked 22,715,151 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,834 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,748 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 185 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.