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Attention Score in Context
| Title |
Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis
|
|---|---|
| Published in |
Frontiers in Psychiatry, January 2013
|
| DOI | 10.3389/fpsyt.2013.00092 |
| Pubmed ID | |
| Authors |
Susanna L. Fryer, Scott W. Woods, Kent A. Kiehl, Vince D. Calhoun, Godfrey D. Pearlson, Brian J. Roach, Judith M. Ford, Vinod H. Srihari, Thomas H. McGlashan, Daniel H. Mathalon |
| Abstract |
Background: The default mode network (DMN) is a set of brain regions typically activated at rest and suppressed during extrinsic cognition. Schizophrenia has been associated with deficient DMN suppression, though the extent to which DMN dysfunction predates psychosis onset is unclear. This study examined DMN suppression during working memory (WM) performance in youth at clinical high-risk (CHR) for psychosis, early schizophrenia (ESZ) patients, and healthy controls (HC). We hypothesized that the DMN would show load-dependent suppression during WM retrieval in HC but not in ESZ, with CHR participants showing an intermediate pattern. Methods: fMRI data were collected from CHR (n = 32), ESZ (n = 22), and HC (n = 54) participants, ages 12-30. DMN regions were defined via seed-based connectivity analysis of resting-state fMRI data from an independent HC sample. Load-dependent deactivations of these DMN regions in response to WM probes were interrogated. Results: Healthy controls showed linear load-dependent increases in DMN deactivation. Significant Group-by-Load interactions were observed in DMN regions including medial prefrontal and lateral posterior parietal cortices. Group-by-Load effects in posterior DMN nodes resulted from less suppression at higher WM loads in ESZ relative to HC, with CHR differing from neither group. In medial prefrontal cortex, suppression of activity at higher WM loads was significantly diminished in both CHR and ESZ groups, relative to HC. In addition, investigation of dorsolateral prefrontal cortex (DLPFC) activations revealed that ESZ activated right DLPFC significantly more than HC, with CHR differing from neither group. Conclusion: While HC showed WM load-dependent modulation of DMN suppression, CHR individuals had deficient higher-load DMN suppression that was similar to, but less pronounced than, the distributed suppression deficits evident in ESZ patients. These results suggest that DMN dysregulation associated with schizophrenia predates psychosis onset. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 1% |
| Turkey | 1 | <1% |
| China | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 131 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 18% |
| Researcher | 24 | 18% |
| Student > Master | 13 | 10% |
| Other | 10 | 7% |
| Student > Bachelor | 9 | 7% |
| Other | 26 | 19% |
| Unknown | 29 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 31 | 23% |
| Medicine and Dentistry | 27 | 20% |
| Neuroscience | 21 | 15% |
| Agricultural and Biological Sciences | 9 | 7% |
| Engineering | 3 | 2% |
| Other | 7 | 5% |
| Unknown | 38 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2013.
All research outputs
#14,760,611
of 22,721,584 outputs
Outputs from Frontiers in Psychiatry
#5,021
of 9,839 outputs
Outputs of similar age
#175,341
of 280,759 outputs
Outputs of similar age from Frontiers in Psychiatry
#122
of 185 outputs
Altmetric has tracked 22,721,584 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,839 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,759 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 185 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.