Title |
Effects of Transcranial Direct Current Stimulation on Consolidation of Fear Memory
|
---|---|
Published in |
Frontiers in Psychiatry, January 2013
|
DOI | 10.3389/fpsyt.2013.00107 |
Pubmed ID | |
Authors |
Manish Asthana, Katharina Nueckel, Andreas Mühlberger, Dorothea Neueder, Thomas Polak, Katharina Domschke, Jürgen Deckert, Martin J. Herrmann |
Abstract |
It has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm, in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assigned into three groups: anodal, cathodal, and sham stimulation. The participants of the two active groups (i.e., anodal and cathodal) received tDCS over the left DLPFC for 12 min after fear conditioning. The effect of fear conditioning and consolidation (24 h later) was measured by assessing the skin conductance response (SCR) to the CS. The results provide evidence that cathodal stimulation of the left DLPFC leads to an inhibitory effect on fear memory consolidation compared to anodal and sham stimulation, as indicated by decreased SCRs to CS+ presentation during extinction training at day 2. In conclusion, current work suggests that cathodal stimulation interferes with processes of fear memory consolidation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 29% |
Switzerland | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 57% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Italy | 1 | <1% |
Germany | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 145 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 27 | 18% |
Student > Master | 26 | 17% |
Student > Bachelor | 24 | 16% |
Student > Ph. D. Student | 18 | 12% |
Student > Doctoral Student | 7 | 5% |
Other | 24 | 16% |
Unknown | 23 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 48 | 32% |
Neuroscience | 29 | 19% |
Medicine and Dentistry | 13 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Agricultural and Biological Sciences | 3 | 2% |
Other | 16 | 11% |
Unknown | 36 | 24% |