Title |
Modulation of the Endocannabinoid System: Vulnerability Factor and New Treatment Target for Stimulant Addiction
|
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Published in |
Frontiers in Psychiatry, January 2013
|
DOI | 10.3389/fpsyt.2013.00109 |
Pubmed ID | |
Authors |
Stéphanie Olière, Antoine Jolette-Riopel, Stéphane Potvin, Didier Jutras-Aswad |
Abstract |
Cannabis is one of the most widely used illicit substance among users of stimulants such as cocaine and amphetamines. Interestingly, increasing recent evidence points toward the involvement of the endocannabinoid system (ECBS) in the neurobiological processes related to stimulant addiction. This article presents an up-to-date review with deep insights into the pivotal role of the ECBS in the neurobiology of stimulant addiction and the effects of its modulation on addictive behaviors. This article aims to: (1) review the role of cannabis use and ECBS modulation in the neurobiological substrates of psychostimulant addiction and (2) evaluate the potential of cannabinoid-based pharmacological strategies to treat stimulant addiction. A growing number of studies support a critical role of the ECBS and its modulation by synthetic or natural cannabinoids in various neurobiological and behavioral aspects of stimulants addiction. Thus, cannabinoids modulate brain reward systems closely involved in stimulants addiction, and provide further evidence that the cannabinoid system could be explored as a potential drug discovery target for treating addiction across different classes of stimulants. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 13 | 22% |
United States | 6 | 10% |
Brazil | 2 | 3% |
Switzerland | 1 | 2% |
Mexico | 1 | 2% |
Canada | 1 | 2% |
Australia | 1 | 2% |
United Arab Emirates | 1 | 2% |
Georgia | 1 | 2% |
Other | 0 | 0% |
Unknown | 32 | 54% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 54 | 92% |
Practitioners (doctors, other healthcare professionals) | 2 | 3% |
Scientists | 1 | 2% |
Unknown | 2 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Pakistan | 1 | <1% |
Unknown | 119 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 21 | 17% |
Researcher | 18 | 15% |
Student > Ph. D. Student | 17 | 14% |
Other | 9 | 7% |
Student > Master | 9 | 7% |
Other | 23 | 19% |
Unknown | 25 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 23 | 19% |
Agricultural and Biological Sciences | 18 | 15% |
Neuroscience | 13 | 11% |
Medicine and Dentistry | 13 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 3% |
Other | 17 | 14% |
Unknown | 34 | 28% |