Title |
Computational Neuropsychiatry – Schizophrenia as a Cognitive Brain Network Disorder
|
---|---|
Published in |
Frontiers in Psychiatry, March 2014
|
DOI | 10.3389/fpsyt.2014.00030 |
Pubmed ID | |
Authors |
Maria R. Dauvermann, Heather C. Whalley, André Schmidt, Graham L. Lee, Liana Romaniuk, Neil Roberts, Eve C. Johnstone, Stephen M. Lawrie, Thomas W. J. Moorhead |
Abstract |
Computational modeling of functional brain networks in fMRI data has advanced the understanding of higher cognitive function. It is hypothesized that functional networks mediating higher cognitive processes are disrupted in people with schizophrenia. In this article, we review studies that applied measures of functional and effective connectivity to fMRI data during cognitive tasks, in particular working memory fMRI studies. We provide a conceptual summary of the main findings in fMRI data and their relationship with neurotransmitter systems, which are known to be altered in individuals with schizophrenia. We consider possible developments in computational neuropsychiatry, which are likely to further our understanding of how key functional networks are altered in schizophrenia. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 38% |
Switzerland | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 50% |
Practitioners (doctors, other healthcare professionals) | 3 | 38% |
Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Unknown | 121 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 15% |
Student > Bachelor | 19 | 15% |
Researcher | 18 | 15% |
Student > Ph. D. Student | 15 | 12% |
Student > Postgraduate | 14 | 11% |
Other | 24 | 20% |
Unknown | 14 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 20% |
Psychology | 22 | 18% |
Neuroscience | 22 | 18% |
Biochemistry, Genetics and Molecular Biology | 10 | 8% |
Agricultural and Biological Sciences | 5 | 4% |
Other | 14 | 11% |
Unknown | 25 | 20% |