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Do Manual and Voxel-Based Morphometry Measure the Same? A Proof of Concept Study

Overview of attention for article published in Frontiers in Psychiatry, April 2014
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Title
Do Manual and Voxel-Based Morphometry Measure the Same? A Proof of Concept Study
Published in
Frontiers in Psychiatry, April 2014
DOI 10.3389/fpsyt.2014.00039
Pubmed ID
Authors

Niels K. Focke, Sarah Trost, Walter Paulus, Peter Falkai, Oliver Gruber

Abstract

Voxel-based morphometry (VBM) is a commonly used method to study volumetric variations on a whole brain basis. However, it is often criticized for potential confounds, mainly based on imperfect spatial registration. We therefore aimed to evaluate if VBM and "gold standard" manual volumetry are measuring the same effects with respect to subcortical gray matter volumes. Manual regions-of-interest were drawn in the hippocampus, amygdala, nucleus accumbens, thalamus, putamen, pallidum, and caudate nucleus bilaterally. Resulting volumes were used for a whole brain VBM correlation analysis with Statistical Parametric Mapping (SPM8). The hippocampus, amygdala, putamen, and caudate nucleus were correctly identified by SPM using the contemporary high-dimensional normalization (DARTEL toolbox). This strongly suggests that VBM and manual volumetry both are indeed measuring the same effects with regard to subcortical brain structures.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Netherlands 1 2%
Australia 1 2%
United Kingdom 1 2%
United States 1 2%
Unknown 50 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 29%
Student > Bachelor 8 15%
Researcher 8 15%
Student > Master 7 13%
Student > Postgraduate 3 5%
Other 6 11%
Unknown 7 13%
Readers by discipline Count As %
Medicine and Dentistry 13 24%
Neuroscience 11 20%
Psychology 7 13%
Engineering 5 9%
Nursing and Health Professions 2 4%
Other 4 7%
Unknown 13 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2014.
All research outputs
#18,370,767
of 22,753,345 outputs
Outputs from Frontiers in Psychiatry
#6,810
of 9,896 outputs
Outputs of similar age
#165,409
of 228,038 outputs
Outputs of similar age from Frontiers in Psychiatry
#30
of 33 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,896 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
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We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.