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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Upregulated GABA Inhibitory Function in ADHD Children with Child Behavior Checklist–Dysregulation Profile: 123I-Iomazenil SPECT Study
|
|---|---|
| Published in |
Frontiers in Psychiatry, June 2015
|
| DOI | 10.3389/fpsyt.2015.00084 |
| Pubmed ID | |
| Authors |
Shinichiro Nagamitsu, Yushiro Yamashita, Hitoshi Tanigawa, Hiromi Chiba, Hayato Kaida, Masatoshi Ishibashi, Tatsuyuki Kakuma, Paul E. Croarkin, Toyojiro Matsuishi |
| Abstract |
The child behavior checklist-dysregulation profile (CBCL-DP) refers to a pattern of elevated scores on the attention problems, aggression, and anxiety/depression subscales of the child behavior checklist. The aim of the present study was to investigate the potential role of GABA inhibitory neurons in children with attention deficit/hyperactivity disorder (ADHD) and dysregulation assessed with a dimensional measure. Brain single photon emission computed tomography (SPECT) was performed in 35 children with ADHD using 123I-iomazenil, which binds with high affinity to benzodiazepine receptors. Iomazenil binding activities were assessed with respect to the presence or absence of a threshold CBCL-DP (a score ≥210 for the sum of the three subscales: Attention Problems, Aggression, and Anxiety/Depression). We then attempted to identify which CBCL-DP subscale explained the most variance with respect to SPECT data, using "age," "sex," and "history of maltreatment" as covariates. Significantly higher iomazenil binding activity was seen in the posterior cingulate cortex (PCC) of ADHD children with a significant CBCL-DP. The Anxiety/Depression subscale on the CBCL had significant effects on higher iomazenil binding activity in the left superior frontal, middle frontal, and temporal regions, as well as in the PCC. The present brain SPECT findings suggest that GABAergic inhibitory neurons may play an important role in the neurobiology of the CBCL-DP, in children with ADHD. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 20% |
| Switzerland | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 77 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 17% |
| Student > Doctoral Student | 11 | 14% |
| Student > Master | 8 | 10% |
| Student > Bachelor | 8 | 10% |
| Researcher | 7 | 9% |
| Other | 12 | 16% |
| Unknown | 18 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 24 | 31% |
| Medicine and Dentistry | 9 | 12% |
| Neuroscience | 8 | 10% |
| Agricultural and Biological Sciences | 3 | 4% |
| Social Sciences | 3 | 4% |
| Other | 5 | 6% |
| Unknown | 25 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2023.
All research outputs
#13,017,095
of 23,511,526 outputs
Outputs from Frontiers in Psychiatry
#3,578
of 10,612 outputs
Outputs of similar age
#117,476
of 269,156 outputs
Outputs of similar age from Frontiers in Psychiatry
#22
of 51 outputs
Altmetric has tracked 23,511,526 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,612 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,156 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.