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Mendeley readers
Attention Score in Context
| Title |
Disturbed Amino Acid Metabolism in HIV: Association with Neuropsychiatric Symptoms
|
|---|---|
| Published in |
Frontiers in Psychiatry, July 2015
|
| DOI | 10.3389/fpsyt.2015.00097 |
| Pubmed ID | |
| Authors |
Johanna M. Gostner, Kathrin Becker, Katharina Kurz, Dietmar Fuchs |
| Abstract |
Blood levels of the amino acid phenylalanine, as well as of the tryptophan breakdown product kynurenine, are found to be elevated in human immunodeficiency virus type 1 (HIV-1)-infected patients. Both essential amino acids, tryptophan and phenylalanine, are important precursor molecules for neurotransmitter biosynthesis. Thus, dysregulated amino acid metabolism may be related to disease-associated neuropsychiatric symptoms, such as development of depression, fatigue, and cognitive impairment. Increased phenylalanine/tyrosine and kynurenine/tryptophan ratios are associated with immune activation in patients with HIV-1 infection and decrease upon effective antiretroviral therapy. Recent large-scale metabolic studies have confirmed the crucial involvement of tryptophan and phenylalanine metabolism in HIV-associated disease. Herein, we summarize the current status of the role of tryptophan and phenylalanine metabolism in HIV disease and discuss how inflammatory stress-associated dysregulation of amino acid metabolism may be part of the pathophysiology of common HIV-associated neuropsychiatric conditions. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Unknown | 74 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 16% |
| Researcher | 11 | 14% |
| Other | 9 | 12% |
| Student > Master | 8 | 11% |
| Student > Bachelor | 7 | 9% |
| Other | 17 | 22% |
| Unknown | 12 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 21% |
| Medicine and Dentistry | 13 | 17% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Psychology | 4 | 5% |
| Immunology and Microbiology | 3 | 4% |
| Other | 14 | 18% |
| Unknown | 18 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2015.
All research outputs
#20,282,766
of 22,816,807 outputs
Outputs from Frontiers in Psychiatry
#7,673
of 9,933 outputs
Outputs of similar age
#219,471
of 262,658 outputs
Outputs of similar age from Frontiers in Psychiatry
#39
of 42 outputs
Altmetric has tracked 22,816,807 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,933 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,658 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.