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Paired-Associative Stimulation-Induced Long-term Potentiation-Like Motor Cortex Plasticity in Healthy Adolescents

Overview of attention for article published in Frontiers in Psychiatry, May 2017
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Title
Paired-Associative Stimulation-Induced Long-term Potentiation-Like Motor Cortex Plasticity in Healthy Adolescents
Published in
Frontiers in Psychiatry, May 2017
DOI 10.3389/fpsyt.2017.00095
Pubmed ID
Authors

Jonathan C. Lee, Paul E. Croarkin, Stephanie H. Ameis, Yinming Sun, Daniel M. Blumberger, Tarek K. Rajji, Zafiris J. Daskalakis

Abstract

The objective of this study was to evaluate the feasibility of using paired-associative stimulation (PAS) to study excitatory and inhibitory plasticity in adolescents while examining variables that may moderate plasticity (such as sex and environment). We recruited 34 healthy adolescents (aged 13-19, 13 males, 21 females). To evaluate excitatory plasticity, we compared mean motor-evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS) before and after PAS at 0, 15, and 30 min. To evaluate inhibitory plasticity, we evaluated the cortical silent period (CSP) elicited by single-pulse TMS in the contracted hand before and after PAS at 0, 15, and 30 min. All participants completed PAS procedures. No adverse events occurred. PAS was well tolerated. PAS-induced significant increases in the ratio of post-PAS MEP to pre-PAS MEP amplitudes (p < 0.01) at all post-PAS intervals. Neither socioeconomic status nor sex was associated with post-PAS MEP changes. PAS induced significant CSP lengthening in males but not females. PAS is a feasible, safe, and well-tolerated index of adolescent motor cortical plasticity. Gender may influence PAS-induced changes in cortical inhibition. PAS is safe and well tolerated by healthy adolescents and may be a novel tool with which to study adolescent neuroplasticity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 17%
Researcher 6 14%
Student > Master 6 14%
Student > Doctoral Student 5 12%
Student > Ph. D. Student 5 12%
Other 3 7%
Unknown 10 24%
Readers by discipline Count As %
Neuroscience 10 24%
Psychology 9 21%
Medicine and Dentistry 2 5%
Business, Management and Accounting 1 2%
Agricultural and Biological Sciences 1 2%
Other 6 14%
Unknown 13 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2017.
All research outputs
#18,547,867
of 22,971,207 outputs
Outputs from Frontiers in Psychiatry
#6,919
of 10,103 outputs
Outputs of similar age
#239,532
of 314,090 outputs
Outputs of similar age from Frontiers in Psychiatry
#61
of 67 outputs
Altmetric has tracked 22,971,207 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,103 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.