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X Demographics
Mendeley readers
Attention Score in Context
| Title |
GABAergic Mechanisms in Schizophrenia: Linking Postmortem and In Vivo Studies
|
|---|---|
| Published in |
Frontiers in Psychiatry, August 2017
|
| DOI | 10.3389/fpsyt.2017.00118 |
| Pubmed ID | |
| Authors |
Jeroen C. de Jonge, Christiaan H. Vinkers, Hilleke E. Hulshoff Pol, Anouk Marsman |
| Abstract |
Schizophrenia is a psychiatric disorder characterized by hallucinations, delusions, disorganized thinking, and impairments in cognitive functioning. Evidence from postmortem studies suggests that alterations in cortical γ-aminobutyric acid (GABAergic) neurons contribute to the clinical features of schizophrenia. In vivo measurement of brain GABA levels using magnetic resonance spectroscopy (MRS) offers the possibility to provide more insight into the relationship between problems in GABAergic neurotransmission and clinical symptoms of schizophrenia patients. This study reviews and links alterations in the GABA system in postmortem studies, animal models, and human studies in schizophrenia. Converging evidence implicates alterations in both presynaptic and postsynaptic components of GABAergic neurotransmission in schizophrenia, and GABA may thus play an important role in the pathophysiology of schizophrenia. MRS studies can provide direct insight into the GABAergic mechanisms underlying the development of schizophrenia as well as changes during its course. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 11% |
| United Kingdom | 1 | 11% |
| Switzerland | 1 | 11% |
| Unknown | 6 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 56% |
| Practitioners (doctors, other healthcare professionals) | 2 | 22% |
| Scientists | 2 | 22% |
Mendeley readers
The data shown below were compiled from readership statistics for 286 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 286 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 52 | 18% |
| Student > Ph. D. Student | 47 | 16% |
| Researcher | 32 | 11% |
| Student > Master | 31 | 11% |
| Student > Doctoral Student | 12 | 4% |
| Other | 38 | 13% |
| Unknown | 74 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 89 | 31% |
| Medicine and Dentistry | 22 | 8% |
| Biochemistry, Genetics and Molecular Biology | 21 | 7% |
| Psychology | 18 | 6% |
| Agricultural and Biological Sciences | 17 | 6% |
| Other | 34 | 12% |
| Unknown | 85 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2023.
All research outputs
#7,807,532
of 25,446,666 outputs
Outputs from Frontiers in Psychiatry
#3,690
of 12,716 outputs
Outputs of similar age
#113,876
of 328,350 outputs
Outputs of similar age from Frontiers in Psychiatry
#39
of 72 outputs
Altmetric has tracked 25,446,666 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 12,716 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,350 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.