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Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder

Overview of attention for article published in Frontiers in Psychiatry, March 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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1 blog
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3 X users

Citations

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16 Dimensions

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46 Mendeley
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Title
Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder
Published in
Frontiers in Psychiatry, March 2018
DOI 10.3389/fpsyt.2018.00090
Pubmed ID
Authors

Delin Sun, Sarah L. Davis, Courtney C. Haswell, Chelsea A. Swanson, Mid-Atlantic MIRECC Workgroup, Kevin S. LaBar, John A. Fairbank, Rajendra A. Morey, Jean C. Beckham, Mira Brancu, Patrick S. Calhoun, Eric Dedert, Eric B. Elbogen, Kimberly T. Green, Robin A. Hurley, Jason D. Kilts, Nathan Kimbrel, Angela Kirby, Christine E. Marx, Gregory McCarthy, Scott D. McDonald, Marinell Miller-Mumford, Scott D. Moore, Rajendra A. Morey, Jennifer C. Naylor, Treven C. Pickett, Jared Rowland, Jennifer J. Runnals, Cindy Swinkels, Steven T. Szabo, Katherine H. Taber, Larry A. Tupler, Elizabeth E. Van Voorhees, H. Ryan Wagner, Richard D. Weiner, Ruth E. Yoash-Gantz

Abstract

Posttraumatic stress disorder (PTSD) is a prevalent, chronic disorder with high psychiatric morbidity; however, a substantial portion of affected individuals experience remission after onset. Alterations in brain network topology derived from cortical thickness correlations are associated with PTSD, but the effects of remitted symptoms on network topology remain essentially unexplored. In this cross-sectional study, US military veterans (N = 317) were partitioned into three diagnostic groups, current PTSD (CURR-PTSD, N = 101), remitted PTSD with lifetime but no current PTSD (REMIT-PTSD, N = 35), and trauma-exposed controls (CONTROL, n = 181). Cortical thickness was assessed for 148 cortical regions (nodes) and suprathreshold interregional partial correlations across subjects constituted connections (edges) in each group. Four centrality measures were compared with characterize between-group differences. The REMIT-PTSD and CONTROL groups showed greater centrality in left frontal pole than the CURR-PTSD group. The REMIT-PTSD group showed greater centrality in right subcallosal gyrus than the other two groups. Both REMIT-PTSD and CURR-PTSD groups showed greater centrality in right superior frontal sulcus than CONTROL group. The centrality in right subcallosal gyrus, left frontal pole, and right superior frontal sulcus may play a role in remission, current symptoms, and PTSD history, respectively. The network centrality changes in critical brain regions and structural networks are associated with remitted PTSD, which typically coincides with enhanced functional behaviors, better emotion regulation, and improved cognitive processing. These brain regions and associated networks may be candidates for developing novel therapies for PTSD. Longitudinal work is needed to characterize vulnerability to chronic PTSD, and resilience to unremitting PTSD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 11%
Student > Doctoral Student 5 11%
Researcher 5 11%
Student > Ph. D. Student 5 11%
Lecturer 3 7%
Other 7 15%
Unknown 16 35%
Readers by discipline Count As %
Psychology 14 30%
Neuroscience 4 9%
Social Sciences 3 7%
Medicine and Dentistry 2 4%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 4 9%
Unknown 17 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2018.
All research outputs
#3,647,720
of 23,025,074 outputs
Outputs from Frontiers in Psychiatry
#1,861
of 10,146 outputs
Outputs of similar age
#72,756
of 329,860 outputs
Outputs of similar age from Frontiers in Psychiatry
#59
of 153 outputs
Altmetric has tracked 23,025,074 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,146 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,860 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 153 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.