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Mendeley readers
Attention Score in Context
| Title |
Cognitive and Neurophysiological Recovery Following Electroconvulsive Therapy: A Study Protocol
|
|---|---|
| Published in |
Frontiers in Psychiatry, May 2018
|
| DOI | 10.3389/fpsyt.2018.00171 |
| Pubmed ID | |
| Authors |
Ben J. A. Palanca, Hannah R. Maybrier, Angela M. Mickle, Nuri B. Farber, R. Edward Hogan, Emma R. Trammel, J. Wylie Spencer, Donald D. Bohnenkamp, Troy S. Wildes, ShiNung Ching, Eric Lenze, Mathias Basner, Max B. Kelz, Michael S. Avidan |
| Abstract |
Electroconvulsive therapy (ECT) employs the elective induction of generalizes seizures as a potent treatment for severe psychiatric illness. As such, ECT provides an opportunity to rigorously study the recovery of consciousness, reconstitution of cognition, and electroencephalographic (EEG) activity following seizures. Fifteen patients with major depressive disorder refractory to pharmacologic therapy will be enrolled (Clinicaltrials.gov, NCT02761330). Adequate seizure duration will be confirmed following right unilateral ECT under etomidate anesthesia. Patients will then undergo randomization for the order in which they will receive three sequential treatments: etomidate + ECT, ketamine + ECT, and ketamine + sham ECT. Sessions will be repeated in the same sequence for a total of six treatments. Before each session, sensorimotor speed, working memory, and executive function will be assessed through a standardized cognitive test battery. After each treatment, the return of purposeful responsiveness to verbal command will be determined. At this point, serial cognitive assessments will begin using the same standardized test battery. The presence of delirium and changes in depression severity will also be ascertained. Sixty-four channel EEG will be acquired throughout baseline, ictal, and postictal epochs. Mixed-effects models will correlate the trajectories of cognitive recovery, clinical outcomes, and EEG metrics over time. This innovative research design will answer whether: (1) time to return of responsiveness will be prolonged with ketamine + ECT compared with ketamine + sham ECT; (2) time of restoration to baseline function in each cognitive domain will take longer after ketamine + ECT than after ketamine + sham ECT; (3) postictal delirium is associated with delayed restoration of baseline function in all cognitive domains; and (4) the sequence of reconstitution of cognitive domains following the three treatments in this study is similar to that occurring after an isoflurane general anesthetic (NCT01911195). Sub-studies will assess the relationships of cognitive recovery to the EEG preceding, concurrent, and following individual ECT sessions. Overall, this study will lead the development of biomarkers for tailoring the cogno-affective recovery of patients undergoing ECT. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 84 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 15% |
| Student > Master | 10 | 12% |
| Researcher | 9 | 11% |
| Other | 7 | 8% |
| Student > Ph. D. Student | 7 | 8% |
| Other | 10 | 12% |
| Unknown | 28 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 15% |
| Psychology | 13 | 15% |
| Neuroscience | 12 | 14% |
| Agricultural and Biological Sciences | 4 | 5% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Other | 10 | 12% |
| Unknown | 28 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2018.
All research outputs
#20,489,895
of 23,052,509 outputs
Outputs from Frontiers in Psychiatry
#7,826
of 10,173 outputs
Outputs of similar age
#287,346
of 326,851 outputs
Outputs of similar age from Frontiers in Psychiatry
#167
of 172 outputs
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