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Reduced Prefrontal Activation During the Tower of London and Verbal Fluency Task in Patients With Bipolar Depression: A Multi-Channel NIRS Study

Overview of attention for article published in Frontiers in Psychiatry, May 2018
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Title
Reduced Prefrontal Activation During the Tower of London and Verbal Fluency Task in Patients With Bipolar Depression: A Multi-Channel NIRS Study
Published in
Frontiers in Psychiatry, May 2018
DOI 10.3389/fpsyt.2018.00214
Pubmed ID
Authors

Linyan Fu, Dan Xiang, Jiawei Xiao, Lihua Yao, Ying Wang, Ling Xiao, Huiling Wang, Gaohua Wang, Zhongchun Liu

Abstract

Background: The Tower of London (TOL) task is one of the most commonly used tests for evaluating executive functions, and can indicate planning and problem-solving abilities. The aim of this study was to evaluate hemodynamic changes between the task period and rest period in patients with bipolar depression during the TOL task and the verbal fluency task (VFT) using near-infrared spectroscopy (NIRS). Methods: Forty-three patients with bipolar depression and 32 healthy controls (HCs) matched for sex, age, handedness, and years of education were enrolled in this study. All participants were aged between 16 and 50. All patients in our study were taking medications such as antidepressants, antipsychotics and mood stabilizers at the time of measurement. Changes in oxygenated hemoglobin (oxy-Hb) levels in frontal areas during the TOL task and VFT were evaluated using a 41-channel NIRS system. Results: During the TOL task, the patients with bipolar depression exhibited significantly smaller changes in the bilateral dorsal-lateral prefrontal cortex (DLPFC) than the HCs. During the VFT task, the patients with bipolar depression exhibited significantly smaller changes in the right ventrolateral prefrontal cortex (VLPFC), the right DLPFC and both the right and left prefrontal cortex (PFC) than the HCs. Limitations: Our sample size was small, and the effects of medication cannot be excluded. Conclusions: These results indicate that planning and problem solving dysfunction is related to the impairment of the prefrontal cortex in patients with bipolar depression, and NIRS can be used to assess planning and problem solving abilities, which are essential to daily life in patients with bipolar disorder.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 19%
Student > Doctoral Student 5 10%
Student > Master 5 10%
Researcher 5 10%
Student > Bachelor 4 8%
Other 3 6%
Unknown 17 35%
Readers by discipline Count As %
Psychology 13 27%
Neuroscience 5 10%
Medicine and Dentistry 4 8%
Physics and Astronomy 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 2 4%
Unknown 22 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2018.
All research outputs
#18,606,163
of 23,047,237 outputs
Outputs from Frontiers in Psychiatry
#6,968
of 10,173 outputs
Outputs of similar age
#255,692
of 330,828 outputs
Outputs of similar age from Frontiers in Psychiatry
#153
of 176 outputs
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