Title |
Biological Mechanisms of Cancer-Induced Depression
|
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Published in |
Frontiers in Psychiatry, July 2018
|
DOI | 10.3389/fpsyt.2018.00299 |
Pubmed ID | |
Authors |
Kimberly Young, Gurmit Singh |
Abstract |
Patients with cancer are more likely to develop depression than the general population, which negatively impacts their quality of life and prognosis. In order to identify effective antidepressants catered toward cancer patients, the biology of depression in the context of cancer must be well-understood. Many theories have emerged postulating the mechanisms underlying the development of depressive disorder. Here, we review the role inflammation, a hyperactive hypothalamic-pituitary-adrenal (HPA) axis, and glutamate excitotoxicity may play in cancer-induced depression. Hopefully, novel therapeutics targeting these dysregulated pathways may be potent in ameliorating depressive symptoms in the cancer population. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 33% |
Canada | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 90 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 14 | 16% |
Student > Master | 8 | 9% |
Student > Doctoral Student | 6 | 7% |
Other | 5 | 6% |
Researcher | 5 | 6% |
Other | 14 | 16% |
Unknown | 38 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 20% |
Neuroscience | 8 | 9% |
Biochemistry, Genetics and Molecular Biology | 8 | 9% |
Nursing and Health Professions | 4 | 4% |
Psychology | 3 | 3% |
Other | 6 | 7% |
Unknown | 43 | 48% |