Title |
A Positive Association between T. gondii Seropositivity and Obesity
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Published in |
Frontiers in Public Health, January 2013
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DOI | 10.3389/fpubh.2013.00073 |
Pubmed ID | |
Authors |
Gloria M. Reeves, Sara Mazaheri, Soren Snitker, Patricia Langenberg, Ina Giegling, Annette M. Hartmann, Bettina Konte, Marion Friedl, Olaoluwa Okusaga, Maureen W. Groer, Harald Mangge, Daniel Weghuber, David B. Allison, Dan Rujescu, Teodor T. Postolache |
Abstract |
Obesity is a global public health problem that is linked with morbidity, mortality, and functional limitations and has limited options for sustained interventions. Novel targets for prevention and intervention require further research into the pathogenesis of obesity. Consistently, elevated markers of inflammation have been reported in association with obesity, but their causes and consequences are not well understood. An emerging field of research has investigated the association of infections and environmental pathogens with obesity, potential causes of low grade inflammation that may mediate obesity risk. In this study, we estimate the possible association between Toxoplasma gondii (T. gondii) infection and obesity in a sample of 999 psychiatrically healthy adults. Individuals with psychiatric conditions, including personality disorders, were excluded because of the association between positive serology to T. gondii and various forms of serious mental illness that have a strong association with obesity. In our sample, individuals with positive T. gondii serology had twice the odds of being obese compared to seronegative individuals (p = 0.01). Further, individuals who were obese had significant higher T. gondii IgG titers compared to individuals who were non-obese. Latent T. gondii infection is very common worldwide, so potential public health interventions related to this parasite can have a high impact on associated health concerns. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Switzerland | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 55 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 12 | 22% |
Researcher | 8 | 15% |
Student > Ph. D. Student | 7 | 13% |
Student > Master | 7 | 13% |
Professor | 4 | 7% |
Other | 12 | 22% |
Unknown | 5 | 9% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 17 | 31% |
Agricultural and Biological Sciences | 10 | 18% |
Immunology and Microbiology | 8 | 15% |
Computer Science | 2 | 4% |
Psychology | 2 | 4% |
Other | 9 | 16% |
Unknown | 7 | 13% |