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Current State of Resistance to Antibiotics of Last-Resort in South Africa: A Review from a Public Health Perspective

Overview of attention for article published in Frontiers in Public Health, September 2016
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Title
Current State of Resistance to Antibiotics of Last-Resort in South Africa: A Review from a Public Health Perspective
Published in
Frontiers in Public Health, September 2016
DOI 10.3389/fpubh.2016.00209
Pubmed ID
Authors

John Osei Sekyere

Abstract

A review of the literature was undertaken to delineate the current level and mechanisms of resistance to carbapenems, colistin, and tigecycline in South Africa. Thirty-two English publications and 32 National Institute of Communicable Diseases communiqués identified between early January 2000 and 20 May, 2016 showed substantial reports of NDM (n = 860), OXA-48 (n = 584), VIM (n = 131), and IMP (n = 45) carbapenemases within this period, mainly in Klebsiella pneumoniae (n = 1138), Acinetobacter baumannii (n = 332), Enterobacter cloacae (n = 201), and Serratia marcescens (n = 108). Colistin and tigecycline resistance was prevalent among K. pneumoniae, A. baumannii, S. marcescens, and E. cloacae. The first mcr-1 colistin resistance gene to be detected in South Africa was reported in Escherichia coli from livestock as well as from hospitalized and outpatients. There are increasing reports of NDM and OXA-48 carbapenemases among Enterobacteriaceae and A. baumannii in South Africa. Mcr-1 is now present in South African patients and livestock. Resistance to carbapenems, colistin, and tigecycline restricts infection management options for clinicians.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Kenya 1 <1%
Unknown 213 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 35 16%
Student > Ph. D. Student 27 13%
Student > Bachelor 22 10%
Researcher 20 9%
Student > Postgraduate 19 9%
Other 30 14%
Unknown 61 29%
Readers by discipline Count As %
Immunology and Microbiology 36 17%
Medicine and Dentistry 27 13%
Agricultural and Biological Sciences 25 12%
Biochemistry, Genetics and Molecular Biology 22 10%
Veterinary Science and Veterinary Medicine 7 3%
Other 24 11%
Unknown 73 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2016.
All research outputs
#15,385,802
of 22,890,496 outputs
Outputs from Frontiers in Public Health
#4,575
of 10,031 outputs
Outputs of similar age
#203,977
of 322,482 outputs
Outputs of similar age from Frontiers in Public Health
#52
of 82 outputs
Altmetric has tracked 22,890,496 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,031 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,482 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.