Title |
Challenges of Generating and Maintaining Protective Vaccine-Induced Immune Responses for Foot-and-Mouth Disease Virus in Pigs
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Published in |
Frontiers in Veterinary Science, November 2016
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DOI | 10.3389/fvets.2016.00102 |
Pubmed ID | |
Authors |
Nicholas A. Lyons, Young S. Lyoo, Donald P. King, David J. Paton |
Abstract |
Vaccination can play a central role in the control of outbreaks of foot-and-mouth disease (FMD) by reducing both the impact of clinical disease and the extent of virus transmission between susceptible animals. Recent incursions of exotic FMD virus lineages into several East Asian countries have highlighted the difficulties of generating and maintaining an adequate immune response in vaccinated pigs. Factors that impact vaccine performance include (i) the potency, antigenic payload, and formulation of a vaccine; (ii) the antigenic match between the vaccine and the heterologous circulating field strain; and (iii) the regime (timing, frequency, and herd-level coverage) used to administer the vaccine. This review collates data from studies that have evaluated the performance of foot-and-mouth disease virus vaccines at the individual and population level in pigs and identifies research priorities that could provide new insights to improve vaccination in the future. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 28% |
Student > Ph. D. Student | 7 | 14% |
Student > Doctoral Student | 4 | 8% |
Student > Master | 4 | 8% |
Other | 3 | 6% |
Other | 5 | 10% |
Unknown | 13 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 12 | 24% |
Agricultural and Biological Sciences | 8 | 16% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Immunology and Microbiology | 3 | 6% |
Medicine and Dentistry | 3 | 6% |
Other | 3 | 6% |
Unknown | 17 | 34% |