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Mendeley readers
Attention Score in Context
| Title |
Gene Expression Profiling Following Maternal Deprivation: Involvement of the Brain Renin-Angiotensin System
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, May 2009
|
| DOI | 10.3389/neuro.02.001.2009 |
| Pubmed ID | |
| Authors |
Claudia Liebl, Markus Panhuysen, Benno Pütz, Dietrich Trümbach, Wolfgang Wurst, Jan M. Deussing, Marianne B. Müller, Mathias V. Schmidt |
| Abstract |
The postnatal development of the mouse is characterized by a stress hypo-responsive period (SHRP), where basal corticosterone levels are low and responsiveness to mild stressors is reduced. Maternal separation is able to disrupt the SHRP and is widely used to model early trauma. In this study we aimed at identifying of brain systems involved in acute and possible long-term effects of maternal separation. We conducted a microarray-based gene expression analysis in the hypothalamic paraventricular nucleus after maternal separation, which revealed 52 differentially regulated genes compared to undisturbed controls, among them are 37 up-regulated and 15 down-regulated genes. One of the prominently up-regulated genes, angiotensinogen, was validated using in-situ hybridization. Angiotensinogen is the precursor of angiotensin II, the main effector of the brain renin-angiotensin system (RAS), which is known to be involved in stress system modulation in adult animals. Using the selective angiotensin type I receptor [AT(1)] antagonist candesartan we found strong effects on CRH and GR mRNA expression in the brain and ACTH release following maternal separation. AT(1) receptor blockade appears to enhance central effects of maternal separation in the neonate, suggesting a suppressing function of brain RAS during the SHRP. Taken together, our results illustrate the molecular adaptations that occur in the paraventricular nucleus following maternal separation and contribute to identifying signaling cascades that control stress system activity in the neonate. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 2% |
| Germany | 1 | 2% |
| Australia | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 43 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 19% |
| Researcher | 8 | 17% |
| Student > Bachelor | 5 | 11% |
| Student > Master | 4 | 9% |
| Student > Doctoral Student | 3 | 6% |
| Other | 10 | 21% |
| Unknown | 8 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 36% |
| Neuroscience | 8 | 17% |
| Biochemistry, Genetics and Molecular Biology | 7 | 15% |
| Medicine and Dentistry | 5 | 11% |
| Arts and Humanities | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 7 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2013.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Frontiers in Molecular Neuroscience
#2,150
of 3,335 outputs
Outputs of similar age
#87,120
of 102,426 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#2
of 2 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,335 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,426 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.