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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic acid animal model of autism
|
|---|---|
| Published in |
Frontiers in Neural Circuits, October 2008
|
| DOI | 10.3389/neuro.04.004.2008 |
| Pubmed ID | |
| Authors |
Tania Rinaldi, Catherine Perrodin, Henry Markram |
| Abstract |
The prefrontal cortex has been extensively implicated in autism to explain deficits in executive and other higher-order functions related to cognition, language, sociability and emotion. The possible changes at the level of the neuronal microcircuit are however not known. We studied microcircuit alterations in the prefrontal cortex in the valproic acid rat model of autism and found that the layer 5 pyramidal neurons are connected to significantly more neighbouring neurons than in controls. These excitatory connections are more plastic displaying enhanced long-term potentiation of the strength of synapses. The microcircuit alterations found in the prefrontal cortex are therefore similar to the alterations previously found in the somatosensory cortex. Hyper-connectivity and hyper-plasticity in the prefrontal cortex implies hyper-functionality of one of the highest order processing regions in the brain, and stands in contrast to the hypo-functionality that is normally proposed in this region to explain some of the autistic symptoms. We propose that a number of deficits in autism such as sociability, attention, multi-tasking and repetitive behaviours, should be re-interpreted in the light of a hyper-functional prefrontal cortex. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 286 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 3% |
| United Kingdom | 2 | <1% |
| France | 2 | <1% |
| Germany | 1 | <1% |
| Chile | 1 | <1% |
| Brazil | 1 | <1% |
| Switzerland | 1 | <1% |
| Mexico | 1 | <1% |
| Netherlands | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 265 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 19% |
| Researcher | 46 | 16% |
| Student > Master | 34 | 12% |
| Student > Bachelor | 32 | 11% |
| Student > Doctoral Student | 21 | 7% |
| Other | 58 | 20% |
| Unknown | 41 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 70 | 24% |
| Neuroscience | 55 | 19% |
| Psychology | 35 | 12% |
| Medicine and Dentistry | 23 | 8% |
| Biochemistry, Genetics and Molecular Biology | 10 | 3% |
| Other | 40 | 14% |
| Unknown | 53 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2019.
All research outputs
#14,228,602
of 22,811,321 outputs
Outputs from Frontiers in Neural Circuits
#660
of 1,216 outputs
Outputs of similar age
#76,577
of 91,792 outputs
Outputs of similar age from Frontiers in Neural Circuits
#1
of 1 outputs
Altmetric has tracked 22,811,321 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,216 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 91,792 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them