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Pausing Purkinje Cells in the Cerebellum of the Awake Cat

Overview of attention for article published in Frontiers in Systems Neuroscience, February 2009
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Title
Pausing Purkinje Cells in the Cerebellum of the Awake Cat
Published in
Frontiers in Systems Neuroscience, February 2009
DOI 10.3389/neuro.06.002.2009
Pubmed ID
Authors

Michael M. Yartsev, Ronit Givon-Mayo, Michael Maller, Opher Donchin

Abstract

A recent controversy has emerged concerning the existence of long pauses, presumably reflecting bistability of membrane potential, in the cerebellar Purkinje cells (PC) of awake animals. It is generally agreed that in the anesthetized animals and in vitro, these cells switch between two stable membrane potential states: a depolarized state (the 'up-state') characterized by continuous firing of simple spikes (SS) and a hyperpolarized state (the 'down-state') characterized by long pauses in the SS activity. To address the existence of long pauses in the neural activity of cerebellar PCs in the awake and behaving animal we used extracellular recordings in cats and find that approximately half of the recorded PCs exhibit such long pauses in the SS activity and transition between activity - periods with uninterrupted SS lasting an average of 1300 ms - and pauses up to several seconds. We called these cells pausing Purkinje cells (PPC) and they can easily be distinguished from continuous firing Purkinje cells. In most PPCs, state transitions in both directions were often associated (25% of state transitions) with complex spikes (CSs). This is consistent with intracellular findings of CS-driven state transitions. In sum, we present proof for the existence of long pauses in the PC SS activity that probably reflect underlying bistability, provide the first in-depth analysis of these pauses and show for the first time that transitions in and out of these pauses are related to CS firing in the awake and behaving animal.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Israel 3 3%
United Kingdom 3 3%
France 1 1%
Germany 1 1%
Canada 1 1%
Singapore 1 1%
Spain 1 1%
United States 1 1%
Unknown 77 87%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 30%
Student > Ph. D. Student 19 21%
Student > Master 10 11%
Professor 7 8%
Student > Bachelor 6 7%
Other 19 21%
Unknown 1 1%
Readers by discipline Count As %
Agricultural and Biological Sciences 37 42%
Neuroscience 21 24%
Engineering 7 8%
Medicine and Dentistry 6 7%
Psychology 6 7%
Other 7 8%
Unknown 5 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2022.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Frontiers in Systems Neuroscience
#650
of 1,407 outputs
Outputs of similar age
#54,825
of 188,872 outputs
Outputs of similar age from Frontiers in Systems Neuroscience
#1
of 2 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,407 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,872 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them