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Mendeley readers
Attention Score in Context
| Title |
Further Evidence for Aberrant Prefrontal Salience Coding in Schizophrenia
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, February 2010
|
| DOI | 10.3389/neuro.08.062.2009 |
| Pubmed ID | |
| Authors |
Henrik Walter, Stephan Heckers, Jan Kassubek, Susanne Erk, Karel Frasch, Birgit Abler |
| Abstract |
The revised dopamine hypothesis of schizophrenia postulates that dopamine metabolism is impacted differently with increased dopamine in the subcortical mesolimbic system and decreased dopamine in prefrontal cortical regions. Recently, we described findings supporting this hypothesis using a financial reward task in patients with schizophrenia (Walter et al., 2009). In addition to analysing prediction and prediction error coding, we found in this study evidence for aberrant cortical representation of salience in the right ventrolateral prefrontal cortex (VLPFC) in patients. Here, we reanalysed data of four other published reward studies of our group in order to investigate (i) whether we could replicate this finding in an independent cohort of patients with schizophrenia and (ii) how dopaminergic modulation impacts on cortical salience representation. Our main result was that we could replicate the finding of aberrant salience coding in the right VLPFC in patients with schizophrenia. Furthermore, we found evidence that the degree of salience coding in this region was correlated inversely with negative symptoms (anhedonia). Results of dopaminergic modulation showed tentative evidence for an influence of dopaminergic stimulation, but were not conclusive. In summary, we conclude that the right VLPFC might play a crucial role in salience coding and is impaired in schizophrenia. |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 4 | 4% |
| United States | 3 | 3% |
| Italy | 2 | 2% |
| Singapore | 1 | 1% |
| Unknown | 86 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 29% |
| Student > Ph. D. Student | 14 | 15% |
| Student > Master | 12 | 13% |
| Other | 7 | 7% |
| Professor > Associate Professor | 7 | 7% |
| Other | 20 | 21% |
| Unknown | 8 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 31 | 32% |
| Medicine and Dentistry | 23 | 24% |
| Agricultural and Biological Sciences | 13 | 14% |
| Neuroscience | 11 | 11% |
| Social Sciences | 2 | 2% |
| Other | 3 | 3% |
| Unknown | 13 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2010.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,399
of 3,461 outputs
Outputs of similar age
#144,326
of 174,037 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#20
of 33 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,461 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,037 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.