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Mendeley readers
Attention Score in Context
| Title |
Enhanced Long-Term Microcircuit Plasticity in the Valproic Acid Animal Model of Autism
|
|---|---|
| Published in |
Frontiers in Synaptic Neuroscience, June 2009
|
| DOI | 10.3389/neuro.19.001.2009 |
| Pubmed ID | |
| Authors |
Guilherme Testa Silva, Jean-Vincent Le Bé, Imad Riachi, Tania Rinaldi, Kamila Markram, Henry Markram |
| Abstract |
A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperconnectivity of glutamatergic synapses and hyperplastic due to over-expression of NMDA receptors. These changes were restricted to the dimensions of a minicolumn (<50 μm). In the present study, we explored whether Long Term Microcircuit Plasticity (LTMP) was altered in this animal model. We performed multi-neuron patch-clamp recordings on clusters of layer 5 pyramidal cells in somatosensory cortex brain slices (PN 12-15), mapped the connectivity and characterized the synaptic properties for connected neurons. Pipettes were then withdrawn and the slice was perfused with 100 μM sodium glutamate in artificial cerebrospinal fluid in the recording chamber for 12 h. When we re-patched the same cluster of neurons, we found enhanced LTMP only at inter-somatic distances beyond minicolumnar dimensions. These data suggest that hyperconnectivity is already near its peak within the dimensions of the minicolumn in the treated animals and that LTMP, which is normally restricted to within a minicolumn, spills over to drive hyperconnectivity across the dimensions of a minicolumn. This study provides further evidence to support the notion that the neocortex is highly plastic in response to new experiences in this animal model of autism. |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 6% |
| Brazil | 2 | 2% |
| Hong Kong | 1 | 1% |
| Netherlands | 1 | 1% |
| France | 1 | 1% |
| Croatia | 1 | 1% |
| Unknown | 81 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 27% |
| Student > Ph. D. Student | 20 | 22% |
| Professor > Associate Professor | 10 | 11% |
| Student > Master | 7 | 8% |
| Professor | 6 | 6% |
| Other | 17 | 18% |
| Unknown | 8 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 28% |
| Neuroscience | 21 | 23% |
| Medicine and Dentistry | 9 | 10% |
| Physics and Astronomy | 5 | 5% |
| Psychology | 4 | 4% |
| Other | 14 | 15% |
| Unknown | 14 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2014.
All research outputs
#6,571,265
of 25,374,647 outputs
Outputs from Frontiers in Synaptic Neuroscience
#116
of 441 outputs
Outputs of similar age
#35,073
of 123,469 outputs
Outputs of similar age from Frontiers in Synaptic Neuroscience
#1
of 1 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 441 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,469 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them