You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Age-Related Neuroinflammatory Changes Negatively Impact on Neuronal Function
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, January 2010
|
| DOI | 10.3389/neuro.24.006.2009 |
| Pubmed ID | |
| Authors |
Marina A Lynch |
| Abstract |
Neuroinflammatory changes, characterized by an increase in microglial activation and often accompanied by upregulation of inflammatory cytokines like interleukin-1beta (IL-1beta), are common to many, if not all, neurodegenerative diseases. Similar, though less dramatic neuroinflammatory changes, are also known to occur with age. Among the consequences of these changes is an impairment in synaptic function and the evidence suggests that inflammatory cytokines may be the primary contributory factor responsible for the deficits in synaptic plasticity which have been identified in aged rodents. Specifically a decrease in the ability of aged rats to sustain long-term potentiation (LTP) in perforant path-granule cells of the hippocampus is associated with increased microglial activation. This review considers the evidence which suggests a causal relationship between these changes and the factors which contribute to the age-related microglial activation, and reflects on data which demonstrate that agents which inhibit microglial activation also improve ability of rats to sustain LTP. |
Mendeley readers
The data shown below were compiled from readership statistics for 176 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 174 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 22% |
| Student > Master | 26 | 15% |
| Researcher | 21 | 12% |
| Student > Bachelor | 20 | 11% |
| Student > Doctoral Student | 11 | 6% |
| Other | 28 | 16% |
| Unknown | 32 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 42 | 24% |
| Neuroscience | 30 | 17% |
| Biochemistry, Genetics and Molecular Biology | 17 | 10% |
| Medicine and Dentistry | 17 | 10% |
| Psychology | 9 | 5% |
| Other | 21 | 12% |
| Unknown | 40 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2013.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Frontiers in Aging Neuroscience
#2,633
of 4,765 outputs
Outputs of similar age
#48,561
of 164,197 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#17
of 28 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,765 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,197 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.