Title |
Local radiotherapy for palliation in multiple myeloma patients with symptomatic bone lesions
|
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Published in |
Radiation Oncology Journal, March 2016
|
DOI | 10.3857/roj.2016.34.1.59 |
Pubmed ID | |
Authors |
Jeong Won Lee, Jeong Eun Lee |
Abstract |
To evaluate the clinical outcomes of symptomatic bone lesions in patients with multiple myeloma (MM) who received local radiotherapy (LRT). Fifty-one patients with 87 symptomatic bone lesions treated via LRT were analyzed. LRT was delivered at a median total dose of 21 Gy (range, 12 to 40 Gy) in a median of 7 fractions (range, 4 to 20 fractions). The clinical outcomes of LRT and the factors affecting treatment response were assessed. After a median follow-up time of 66.7 weeks, symptom relief was achieved for 85 of 87 lesions (97.7%). The median time to symptom relief was 7 days from the start of LRT (range, 1 to 67 days). The duration of in-field failure-free survival ranged from 1.1 to 450.9 weeks (median, 66.7 weeks). The radiation dose or use of previous and concurrent chemotherapy was not significantly associated with in-field failure for LRT (p = 0.354, 0.758, and 0.758, respectively). Symptomatic bone lesions in patients with MM can be successfully treated with LRT. A higher radiation dose or the use of concurrent chemotherapy may not influence the in-field disease control. A relatively low radiation dose could achieve remission of symptoms in patients with MM. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 25% |
Student > Doctoral Student | 3 | 19% |
Researcher | 2 | 13% |
Student > Master | 2 | 13% |
Other | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 38% |
Nursing and Health Professions | 3 | 19% |
Neuroscience | 1 | 6% |
Engineering | 1 | 6% |
Unknown | 5 | 31% |