Title |
Accidental Overdose of Multiple Chemotherapeutic Agents
|
---|---|
Published in |
The Korean Journal of Internal Medicine, July 1989
|
DOI | 10.3904/kjim.1989.4.2.171 |
Pubmed ID | |
Authors |
In Soon Kim, A. Gratwohl, C. Stebler, M. Hausmann, A. Tichelli, A. Stern, B. Speck |
Abstract |
A 35-year-old man with refractory low grade diffuse centroblastic centrocytic non-Hodgkin's lymphoma was treated accidentally with an overdose of multiple chemotherapeutic agents. He was given adriamycin 50 mg/m2 and cyclophosphamide 350 mg/m2 for 6 days followed by 4 days of vincristine 1 mg/m2 and bleomycin 10 mg/m2. He was transferred when he developed pancytopenia, fever, severe mucositis, ileus and peripheral neuropathy. He was treated with broad spectrum antibiotics, red cell and single donor platelet transfusions and strict parenteral nutrition. In addition, he was given a continuous infusion of 400 micrograms daily human recombinant granulocyte macrophage-colony stimulating factor (rh GM-CSF) for 17 days. Intractable severe bleeding from his oral mucositis necessitated treatment with a continuous infusion of 8-ornithine-vasopressin for 8 days. He recovered and could be discharged home after 36 days of hospitalization with normal blood counts and without severe sequelae. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 17% |
Student > Master | 3 | 17% |
Other | 2 | 11% |
Researcher | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Other | 3 | 17% |
Unknown | 3 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 39% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Nursing and Health Professions | 1 | 6% |
Unspecified | 1 | 6% |
Other | 2 | 11% |
Unknown | 3 | 17% |