Title |
Clinicopathological Features and Type of Surgery for Lynch Syndrome: Changes during the Past Two Decades
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Published in |
Cancer Research and Treatment : Official Journal of Korean Cancer Association, May 2015
|
DOI | 10.4143/crt.2015.092 |
Pubmed ID | |
Authors |
Il Tae Son, Duck-Woo Kim, Seung-Yong Jeong, Young-Kyoung Shin, Myong Hoon Ihn, Heung-Kwon Oh, Sung-Bum Kang, Kyu Joo Park, Jae Hwan Oh, Ja-Lok Ku, Jae-Gahb Park |
Abstract |
The Korean Hereditary Tumor Registry, the first and one of the largest registries of hereditary tumors in Korea, has registered about 500 families with hereditary cancer syndromes. This study evaluates the temporal changes in clinicopathologic features and surgical patterns of LS patients. Data on 182 unrelated LS patients were collected retrospectively. The patients were divided into the period 1 group (registered in 1990-2004) and 2 (registered in 2005-2014). The clinical characteristics of the two groups were compared to identify changes over time. The period 1 group included 76 patients and the period 2 group 106 patients. The mean ages at diagnosis were 45.1 years (range, 13-85) for group 1 and 49.7 years (range 20-84) for group 2 (p = 0.015). The TNM stage at diagnosis did not differ significantly: <Period 1 group> stage 0-I (n=18, 23.7%), II (n=37, 48.7%), III (n=19, 25.0%), IV (n=2, 2.6%); <Period 2 group> stage 0-I (n=30, 28.3%), II (n=35, 33.0%), III (n=37, 34.9%), IV (n=4, 3.8%). Extended resection was more frequently performed (55/76, 72.4%) in the period 1 group than period 2 (49/106, 46.2%) (p = 0.001). s Colorectal cancer in patients with LS registered at the KHTR is still diagnosed at an advanced stage, more than two decades after registry's establishment. Segmental resection was more frequently performed in the past decade. A prompt nationwide effort to raise public awareness of hereditary colorectal cancer and to support hereditary cancer registries is required in Korea. |
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Geographical breakdown
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Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Librarian | 2 | 8% |
Student > Ph. D. Student | 2 | 8% |
Researcher | 2 | 8% |
Student > Master | 2 | 8% |
Other | 6 | 25% |
Unknown | 6 | 25% |
Readers by discipline | Count | As % |
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Social Sciences | 2 | 8% |
Agricultural and Biological Sciences | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 21% |