Title |
Invasive strategy and frailty in very elderly patients with acute coronary syndromes.
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Published in |
EuroIntervention, June 2018
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DOI | 10.4244/eij-d-18-00099 |
Pubmed ID | |
Authors |
Isaac Llaó, Albert Ariza-Solé, Juan Sanchis, Oriol Alegre, Ramon López-Palop, Francesc Formiga, Francisco Marín, María T Vidán, Manuel Martínez-Sellés, Alessandro Sionis, Miguel Vives-Borrás, Joan Antoni Gómez-Hospital, Josep Gómez-Lara, Gerard Roura, Pablo Díez-Villanueva, Iván Núñez-Gil, Jaume Maristany, Lluis Asmarats, Héctor Bueno, Emad Abu-Assi, Àngel Cequier |
Abstract |
Current guidelines recommend an early invasive strategy in patients with non-ST segment elevation acute coronary syndromes (NSTEACS). The role of an invasive strategy in frail elderly patients remains controversial. The LONGEVO-SCA registry included unselected NSTEACS patients aged ≥80 years. A geriatric assessment was performed during hospitalization, including frailty. We evaluated the impact of an invasive strategy during the admission on the incidence of cardiac death, reinfarction or new revascularisation at 6-months. From 531 patients included, 145 (27.3%) were frail. Mean age was 84.3 years. Most patients underwent an invasive strategy (407/531, 76.6%). Patients undergoing an invasive strategy were younger and had lower proportion of frailty (23.3% vs 40.3%, p<0.001). The incidence of cardiac events was more common in patients managed conservatively, after adjusting for confounding factors (sub-Hazard ratio (sHR) 2.32, 95% confidence interval (CI) 1.26-4.29, p=0.007). This association remained significant in non-frail patients (sHR 3.85, 95% CI 2.13-6.95, p=0.001), but was not significant in patients with established frailty criteria (sHR 1.40, 95% CI 0.72-2.75, p=0.325). The interaction invasive strategy-frailty was significant (p=0.032) Conclusions: An invasive strategy was independently associated with better outcomes in very elderly patients with NSTEACS. This association was different according to frailty status. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 11 | 19% |
United Kingdom | 7 | 12% |
United States | 6 | 11% |
France | 3 | 5% |
Australia | 2 | 4% |
Germany | 2 | 4% |
Argentina | 2 | 4% |
Lebanon | 1 | 2% |
Chile | 1 | 2% |
Other | 4 | 7% |
Unknown | 18 | 32% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 30 | 53% |
Practitioners (doctors, other healthcare professionals) | 11 | 19% |
Scientists | 11 | 19% |
Science communicators (journalists, bloggers, editors) | 5 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 6 | 12% |
Student > Ph. D. Student | 6 | 12% |
Researcher | 6 | 12% |
Student > Doctoral Student | 3 | 6% |
Student > Master | 3 | 6% |
Other | 7 | 14% |
Unknown | 20 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 31% |
Nursing and Health Professions | 5 | 10% |
Social Sciences | 2 | 4% |
Agricultural and Biological Sciences | 1 | 2% |
Unspecified | 1 | 2% |
Other | 2 | 4% |
Unknown | 24 | 47% |