| Title |
Iberian cured-ham consumption improves endothelial function in healthy subjects
|
|---|---|
| Published in |
The journal of nutrition, health & aging, December 2017
|
| DOI | 10.1007/s12603-016-0848-1 |
| Pubmed ID | |
| Authors |
Jose Saban-Ruiz, M. Fabregate-Fuente, R. Fabregate-Fuente, A. Andres-Castillo, A. Palomino-Antolin, D. Barrio-Carreras, L. Martin-Fernandez, F. Altamirano, C. Fernandez-Fernandez, C. Andres-Lacueva |
| Abstract |
Previous studies have shown that dietary components such as oleic acid or polyphenols exert beneficial effects on endothelium. We aimed to assess the impact of regular consumption of Iberian cured-ham (ICH) on endothelial function. An open-label, randomized controlled parallel study. Volunteers recruited through advertisements at a hospital in Madrid, Spain. 102 Caucasian adults (76.8% females) aged 25-55 years, and free from cardiometabolic disease. Participants were randomized to an ICH-enriched ad libitum diet or an ad libitum diet without ICH for 6 weeks. Subjects in ICH group were randomly provided with either acorn- or mixed-fed ICH, and followed up for an additional 6-week period under their usual diet. Clinical parameters, biomarkers of endothelial function and oxidative stress, microvascular vasodilatory response to hyperemia and arterial stiffness were measured before and after the intervention. After 6 weeks, a larger decrease in PAI-1 was observed in subjects consuming ICH compared to the Control group (-6.2±17.7 vs. 0.3±1.4 ng/ml; p=0.020). Similarly, microvascular vasodilatory response to hyperemia showed a significant increase (112.4±391.7 vs. -56.0±327.9%; p=0.007). However, neither oxidative stress, hemodynamic nor clinical parameters differed significantly over the study. Additionally, after stopping ICH consumption, improvements in PAI-1 remained for 6 additional weeks with respect to baseline (p=0.006). The present study demonstrates, for the first time, that regular consumption of ICH improves endothelial function in healthy adults. Strategies aimed to preserve or improve the endothelial function may have implications in vascular aging beyond the prevention of the atherothrombotic disease. |
X Demographics
The data shown below were collected from the profiles of 101 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 44 | 44% |
| Mexico | 2 | 2% |
| Germany | 2 | 2% |
| United States | 1 | <1% |
| Grenada | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 50 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 87 | 86% |
| Practitioners (doctors, other healthcare professionals) | 10 | 10% |
| Scientists | 3 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 20% |
| Unspecified | 8 | 16% |
| Student > Bachelor | 6 | 12% |
| Other | 2 | 4% |
| Professor | 2 | 4% |
| Other | 7 | 14% |
| Unknown | 14 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 18% |
| Unspecified | 8 | 16% |
| Agricultural and Biological Sciences | 3 | 6% |
| Nursing and Health Professions | 2 | 4% |
| Veterinary Science and Veterinary Medicine | 2 | 4% |
| Other | 9 | 18% |
| Unknown | 16 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 91. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2024.
All research outputs
#477,628
of 25,732,188 outputs
Outputs from The journal of nutrition, health & aging
#43
of 2,002 outputs
Outputs of similar age
#10,613
of 447,206 outputs
Outputs of similar age from The journal of nutrition, health & aging
#1
of 63 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,002 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.