| Title |
Hyperinsulinemia: a Cause of Obesity?
|
|---|---|
| Published in |
Current Obesity Reports, May 2017
|
| DOI | 10.1007/s13679-017-0261-z |
| Pubmed ID | |
| Authors |
Karel A. Erion, Barbara E. Corkey |
| Abstract |
This perspective is motivated by the need to question dogma that does not work: that the problem is insulin resistance (IR). We highlight the need to investigate potential environmental obesogens and toxins. The prequel to severe metabolic disease includes three interacting components that are abnormal: (a) IR, (b) elevated lipids and (c) elevated basal insulin (HI). HI is more common than IR and is a significant independent predictor of diabetes. We hypothesize that (1) the initiating defect is HI that increases nutrient consumption and hyperlipidemia (HL); (2) the cause of HI may include food additives, environmental obesogens or toxins that have entered our food supply since 1980; and (3) HI is sustained by HL derived from increased adipose mass and leads to IR. We suggest that HI and HL are early indicators of metabolic dysfunction and treating and reversing these abnormalities may prevent the development of more serious metabolic disease. |
X Demographics
The data shown below were collected from the profiles of 125 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 28 | 22% |
| United Kingdom | 12 | 10% |
| Canada | 6 | 5% |
| Australia | 6 | 5% |
| Brazil | 4 | 3% |
| Spain | 2 | 2% |
| Norway | 2 | 2% |
| Denmark | 2 | 2% |
| Ireland | 2 | 2% |
| Other | 12 | 10% |
| Unknown | 49 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 79 | 63% |
| Practitioners (doctors, other healthcare professionals) | 28 | 22% |
| Scientists | 17 | 14% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 197 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 13% |
| Student > Master | 26 | 13% |
| Other | 23 | 12% |
| Student > Bachelor | 23 | 12% |
| Student > Ph. D. Student | 22 | 11% |
| Other | 27 | 14% |
| Unknown | 50 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 49 | 25% |
| Biochemistry, Genetics and Molecular Biology | 30 | 15% |
| Nursing and Health Professions | 21 | 11% |
| Agricultural and Biological Sciences | 17 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Other | 16 | 8% |
| Unknown | 58 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 136. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2024.
All research outputs
#308,252
of 25,582,611 outputs
Outputs from Current Obesity Reports
#26
of 424 outputs
Outputs of similar age
#6,369
of 325,405 outputs
Outputs of similar age from Current Obesity Reports
#2
of 12 outputs
Altmetric has tracked 25,582,611 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 424 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,405 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.