| Title |
Minimal dose of milk protein concentrate to enhance the anabolic signalling response to a single bout of resistance exercise; a randomised controlled trial
|
|---|---|
| Published in |
Journal of the International Society of Sports Nutrition, April 2022
|
| DOI | 10.1186/s12970-017-0175-x |
| Pubmed ID | |
| Authors |
Cameron J. Mitchell, Nina Zeng, Randall F. D’Souza, Sarah M. Mitchell, Kirsten Aasen, Aaron C. Fanning, Sally D. Poppitt, David Cameron-Smith |
| Abstract |
Resistance training is a potent stimulus to induce muscle hypertrophy. Supplemental protein intake is known to enhance gains in muscle mass through activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway, which initiates protein translation. While the optimal dose of high quality protein to promote post exercise anabolism in young or older men has been investigated, little is known about the minimum doses of protein required to potentiate the resistance exercise activation of anabolic signalling in middle aged men. Twenty healthy men (46.3 ± 5.7 years, BMI: 23.9 ± 6.6 kg/m(2)) completed a single bout of unilateral resistance exercise consisting of 4 sets of leg extension and press at 80% of 1 repetition maximum. Participants were randomised to consume either formulated milk product containing 9 g milk protein (FMP) or an isoenergetic carbohydrate placebo (CHO) immediately post exercise, in a double blind fashion. A single muscle biopsy was collected at pre-exercise baseline and then bilateral biopsies were collected 90 and 240 min after beverage consumption. P70S6K(Thr389) phosphorylation was increased with exercise irrespective of group, P70S6K(Thr421/Ser424) was increased with exercise only in the FMP group at 240 min. Likewise, rpS6 (Ser235/236) phosphorylation was increased with exercise irrespective of group, rpS6 (Ser240/244) increased to a greater extent following exercise in the FMP group. mRNA expression of the amino acid transporter, LAT1/ SLC7A5 increased with both exercise and beverage consumption irrespective of group. PAT1/ SLC36A1, CAT1/ SLC7A1 and SNAT2/ SLC38A2 mRNA increased only after exercise regardless of group. Nine grams of milk protein is sufficient to augment some measures of downstream mTORC1 signalling after resistance exercise but does not potentiate exercise induced increases in amino acid transporter expression. Formulated products containing nine grams of milk protein would be expected stimulate muscle anabolism after resistance exercise. New Zealand Clinical Trials Registry ACTRN12615001375549. Registered: 17 December, 2015. |
X Demographics
The data shown below were collected from the profiles of 35 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 37% |
| Canada | 3 | 9% |
| South Africa | 2 | 6% |
| Spain | 2 | 6% |
| Japan | 1 | 3% |
| Philippines | 1 | 3% |
| Chile | 1 | 3% |
| Taiwan | 1 | 3% |
| United Kingdom | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 9 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 40% |
| Practitioners (doctors, other healthcare professionals) | 13 | 37% |
| Scientists | 7 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 144 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 20 | 14% |
| Student > Master | 17 | 12% |
| Researcher | 15 | 10% |
| Student > Ph. D. Student | 11 | 8% |
| Professor | 7 | 5% |
| Other | 25 | 17% |
| Unknown | 49 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 22 | 15% |
| Biochemistry, Genetics and Molecular Biology | 21 | 15% |
| Nursing and Health Professions | 21 | 15% |
| Medicine and Dentistry | 12 | 8% |
| Agricultural and Biological Sciences | 7 | 5% |
| Other | 7 | 5% |
| Unknown | 54 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 108. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2022.
All research outputs
#392,219
of 25,601,426 outputs
Outputs from Journal of the International Society of Sports Nutrition
#129
of 950 outputs
Outputs of similar age
#10,766
of 448,720 outputs
Outputs of similar age from Journal of the International Society of Sports Nutrition
#125
of 852 outputs
Altmetric has tracked 25,601,426 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 950 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 64.3. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 448,720 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 852 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.