| Title |
Hyperglucagonaemia analysed by glucagon sandwich ELISA: nonspecific interference or truly elevated levels?
|
|---|---|
| Published in |
Diabetologia, June 2014
|
| DOI | 10.1007/s00125-014-3283-z |
| Pubmed ID | |
| Authors |
Nicolai J. Wewer Albrechtsen, Bolette Hartmann, Simon Veedfald, Johanne A. Windeløv, Astrid Plamboeck, Kirstine N. Bojsen-Møller, Thomas Idorn, Bo Feldt-Rasmussen, Filip K. Knop, Tina Vilsbøll, Sten Madsbad, Carolyn F. Deacon, Jens J. Holst |
| Abstract |
Hyperglucagonaemia is a characteristic of several clinical conditions (e.g. end-stage renal disease (ESRD), type 2 diabetes, obesity before and after Roux-en-Y gastric bypass (RYGB) and vagotomy with pyloroplasty), but the molecular nature of 'immunoreactive' glucagon is poorly characterised. The specific determination of fully processed, intact glucagon requires a 'sandwich' assay employing a combination of antibodies directed against both N- and C-termini. We compared a novel assay for intact glucagon with a highly sensitive C-terminal RIA (hitherto considered specific) to determine the extent to which the hyperglucagonaemia measured in clinical samples was caused by authentic glucagon. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 2 | 2% |
| Sweden | 1 | <1% |
| Unknown | 117 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 26% |
| Student > Ph. D. Student | 28 | 23% |
| Student > Master | 15 | 13% |
| Other | 9 | 8% |
| Student > Bachelor | 7 | 6% |
| Other | 13 | 11% |
| Unknown | 17 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 53 | 44% |
| Biochemistry, Genetics and Molecular Biology | 14 | 12% |
| Agricultural and Biological Sciences | 14 | 12% |
| Chemistry | 4 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 11 | 9% |
| Unknown | 20 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2022.
All research outputs
#6,476,679
of 22,971,207 outputs
Outputs from Diabetologia
#2,614
of 5,082 outputs
Outputs of similar age
#61,609
of 228,593 outputs
Outputs of similar age from Diabetologia
#26
of 70 outputs
Altmetric has tracked 22,971,207 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 5,082 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,593 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.