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Structural Genomics and Drug Discovery

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Cover of 'Structural Genomics and Drug Discovery'

Table of Contents

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    Book Overview
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    Chapter 1 Data Management in the Modern Structural Biology and Biomedical Research Environment
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    Chapter 2 Structural Genomics of Human Proteins
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    Chapter 3 Target Selection for Structural Genomics of Infectious Diseases
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    Chapter 4 Selecting Targets from Eukaryotic Parasites for Structural Genomics and Drug Discovery
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    Chapter 5 High-throughput cloning for biophysical applications.
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    Chapter 6 Expression and solubility testing in a high-throughput environment.
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    Chapter 7 Protein Production for Structural Genomics Using E. coli Expression
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    Chapter 8 Eukaryotic Expression Systems for Structural Studies
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    Chapter 9 Automated Cell-Free Protein Production Methods for Structural Studies
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    Chapter 10 Parallel Protein Purification
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    Chapter 11 Oxidative Refolding from Inclusion Bodies
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    Chapter 12 High-Throughput Crystallization Screening
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    Chapter 13 Screening Proteins for NMR Suitability
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    Chapter 14 Salvage or Recovery of Failed Targets by In Situ Proteolysis
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    Chapter 15 Salvage of Failed Protein Targets by Reductive Alkylation
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    Chapter 16 Salvage or Recovery of Failed Targets by Mutagenesis to Reduce Surface Entropy
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    Chapter 17 Data collection for crystallographic structure determination.
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    Chapter 18 Structure Determination, Refinement, and Validation
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    Chapter 19 Virtual high-throughput ligand screening.
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    Chapter 20 Ligand Screening Using Fluorescence Thermal Shift Analysis (FTS)
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    Chapter 21 Ligand Screening Using Enzymatic Assays
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    Chapter 22 Ligand Screening Using NMR
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    Chapter 23 Screening Ligands by X-ray Crystallography
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    Chapter 24 Case study-structural genomics and human protein kinases.
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Title
Structural Genomics and Drug Discovery
Published by
Springer New York, July 2014
DOI 10.1007/978-1-4939-0354-2
ISBNs
978-1-4939-0353-5, 978-1-4939-0354-2
Editors

Anderson, Wayne F.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 25%
Student > Master 5 25%
Student > Bachelor 2 10%
Professor 1 5%
Other 1 5%
Other 2 10%
Unknown 4 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 50%
Agricultural and Biological Sciences 2 10%
Chemistry 2 10%
Engineering 2 10%
Materials Science 1 5%
Other 1 5%
Unknown 2 10%